"Porous particle-laden turbulent and laminar oscillating and steady flow in multiple branching"@en . "http://www.isvav.cz/projectDetail.do?rowId=GAP105/11/1339"^^ . . . "Odlo\u017Een\u00E1 z\u00E1v\u011Bre\u010Dn\u00E1 zpr\u00E1va"@cs . "0"^^ . . . . "Deferred Final Report"@en . . . . . . "2011-01-01+01:00"^^ . "V r\u00E1mci p\u0159edkl\u00E1dan\u00E9ho projektu bude realizov\u00E1n experiment\u00E1ln\u00ED \u201Ein vitro\u201D v\u00FDzkum transportu a depozice velk\u00FDch por\u00E9zn\u00EDch \u010D\u00E1stic v\u00A0realistick\u00FDch modelech mnoho\u010Detn\u011B v\u011Btven\u00E9ho d\u00FDchac\u00EDho traktu v\u010Detn\u011B \u00FAstn\u00ED dutiny a trachey v\u00A0oscila\u010Dn\u00EDm a ust\u00E1len\u00E9m lamin\u00E1rn\u00EDm a turbulentn\u00EDm re\u017Eimu, tj. jak p\u0159i pln\u00E9m d\u00FDchac\u00EDm cyklu tak p\u0159i ust\u00E1len\u00E9m vdechu. V\u00A0posledn\u00EDm desetilet\u00ED je dokumentov\u00E1n v\u00FDrazn\u00FD n\u00E1r\u016Fst l\u00E9\u010Dby pomoc\u00ED inhalovan\u00FDch farmaceutick\u00FDch aerosol\u016F. Aby byla zaji\u0161t\u011Bna \u00FA\u010Dinnost tohoto zp\u016Fsobu l\u00E9\u010Dby, je nutn\u00E9, aby aerosoly neskon\u010Dili sv\u016Fj \u201E\u017Eivot\u201C v prvn\u00EDch stupn\u00EDch tracheobronchi\u00E1ln\u00EDho stromu. \u010C\u00E1stice proto mus\u00ED m\u00EDt vhodn\u00FD tvar a velikost. V\u00A0n\u011Bkter\u00FDch klinick\u00FDch studi\u00EDch byla prok\u00E1z\u00E1na zv\u00FD\u0161en\u00E1 \u00FA\u010Dinnost depozice tzv. velk\u00FDch por\u00E9zn\u00EDch \u010D\u00E1stic s\u00A0hustotou \u0159\u00E1du 0.1 g/cm3. V projektu bude studov\u00E1n transport a depozice standardn\u00EDch a velk\u00FDch por\u00E9zn\u00EDch \u010D\u00E1stic r\u016Fzn\u00FDch charakteristik v\u00A0jednotliv\u00FDch \u010D\u00E1stech modelu d\u00FDchac\u00EDho traktu vhodn\u00FDmi metodami (PDA, fluorometrie) a vliv turbulence generovan\u00E9 v\u00A0horn\u00EDch d\u00FDchac\u00EDch cest\u00E1ch na depozici v\u00A0jednotliv\u00FDch bifurkac\u00EDch. Bude zdokonalena technologie v\u00FDroby fyzik\u00E1ln\u00EDho modelu d\u00FDchac\u00EDho traktu a ve spolupr\u00E1ci s\u00A0PET centrem Masarykova onkologick\u00E9ho \u00FAstavu v Brn\u011B testov\u00E1na metoda Positron Emission Tomografie na studium depozice. \u00A0" . "GAP105/11/1339" . . . "Oscila\u010Dn\u00ED a ust\u00E1len\u00E9 turbulentn\u00ED a lamin\u00E1rn\u00ED proud\u011Bn\u00ED s por\u00E9zn\u00EDmi \u010D\u00E1sticemi v mnoho\u010Detn\u00FDch v\u011Btven\u00EDch" . . "2015-04-23+02:00"^^ . . "In the frame of the submitted proposal, experimental research \u201Cin vitro\u201D will be conducted of transport and deposition of large porous particles in realistic models of multiple branching respiratory tract including mouth/throat and trachea in oscillating and steady laminar and turbulent regime, i.e. at full breathing cycle and at steady inspiration. Over the past decade, it is documented a sharply increased \u00A0medical treatment using inhaled pharmaceutical aerosols. To ensure the efficiency of this mode of medication, it is necessary that aerosols don\u2019t end their life in early stages of the tracheobronchial tree. Particles must have an appropriate shape and density. In some clinical studies, increased deposition efficiency was proved of large porous particles with density appr. 0.1 g/cm3. In the project, transport and deposition of standard and large porous particles of various characteristics in individual segments of the respiratory tract will be studied using appropriate methods (PDA, fluorometrie) as well as the influence of turbulence generated in upper airways on the deposition in the individual bifurcations. Also, technology to fabricate physical models of respiratory tract will be improved and in collaboration with PET Centre of Masaryk Oncology Institute in Brno, Positron Emission Tomografie will be tested for studies of deposition."@en . . "2014-03-31+02:00"^^ . "0"^^ . . "turbulent flow oscillation porous particles"@en . . "2016-12-31+01:00"^^ . "25"^^ . "25"^^ . "1"^^ . .