"0"^^ . . " free radicals" . "2008-12-31+01:00"^^ . . "14"^^ . "2008-04-25+02:00"^^ . "14"^^ . "2006-01-01+01:00"^^ . . . "Chronick\u00E1 exposice v prost\u0159ed\u00ED s vysok\u00FDm obsahem organick\u00E9ho prachu m\u00E1 celou \u0159adu negativn\u00EDch vliv\u016F na zdrav\u00ED zejm\u00E9na hospod\u00E1\u0159sk\u00FDch zv\u00ED\u0159at a pracovn\u00EDk\u016F v zem\u011Bd\u011Blstv\u00ED. Bakteri\u00E1ln\u00ED endotoxin (LPS) byl prok\u00E1z\u00E1n jako hlavn\u00ED faktor v pathologii chronick\u00E9ho z\u00E1n\u011Btu plic vyvolan\u00E9ho organick\u00FDm prachem. Reaktivn\u00ED metabolity kysl\u00EDku a dus\u00EDku (RMKD) jsou zapojeny do mechanismu LPS vyvolan\u00E9 toxicity d\u00EDky naru\u0161en\u00ED redox senzitivn\u00EDch sign\u00E1ln\u00EDch drah a p\u0159\u00EDm\u00FDm po\u0161kozov\u00E1n\u00EDm bun\u011Bk. D\u016Fle\u017Eit\u00FDm zdrojem RMKD a dal\u0161\u00EDch pro-z\u00E1n\u011Btliv\u00FDch medi\u00E1tor\u016F jsou jak fagocyty tak bu\u0148ky plicn\u00EDho epitelu. V\u00FDznamnou charakteristikou chronick\u00E9ho z\u00E1n\u011Btu plic je redox senzitivn\u00ED hypersekrece mucinu a zv\u00FD\u0161en\u00ED jeho viskozity.\u00A0 Na\u0161\u00ED hypot\u00E9zou je, \u017Ee vy\u010Derpan\u00ED antioxida\u010Dn\u00ED obrany v plic\u00EDch v d\u016Fsledku chronick\u00E9ho z\u00E1n\u011Btu je hlavn\u00EDm mechanismem p\u0159isp\u00EDvaj\u00EDc\u00EDm k patogenezi plicn\u00EDho z\u00E1n\u011Btu vyvolan\u00E9ho chronickou expozic\u00ED k LPS.\u00A0Hlavn\u00EDm c\u00EDlem\u00A0pr\u00E1ce je\u00A0charakterizace produkce RKMD, modulace redox senzitivn\u00EDch sign\u00E1ln\u00EDch drah, naru\u0161en\u00ED\u00A0 antioxida\u010Dn\u00ED" . "2009-10-22+02:00"^^ . . . "Chronic exposures to environments with high content of organic dust have wide ranges of adverse\u00A0health effects with major health impact on farm animals and workers. Bacterial endotoxin\u00A0(LPS) was shown to be the main\u00A0factor in the pathology of organic dust induced chronic lung inflammations. Reactive oxygen and nitrogen species (RONS) are involved, due to an impairment of redox sensitive signalling pathways and a direct cell injury, in the mechanism of LPS\u00A0mediated toxicity. Significant sources of RONS and other pro-inflammatory mediators in the inflamed lungs are both phagocytes\u00A0and lung epithelial cells. An important feature of chronic lung inflammation\u00A0is redox sensitive mucus hypersecretion and increment of\u00A0mucus viscosity.\u00A0We hypothesize the exhausted antioxidant defence in lungs as a consequence of the chronic inflammation is a\u00A0crucial mechanism contributing to the pathology of lung inflammation induced by chronic LPS\u00A0exposure. The aims of the study are to characterize LPS"@en . "Role of free radicals in the regulation of lung inflammation induced by acute and chronic exposure to endotoxin"@en . . . . "http://www.isvav.cz/projectDetail.do?rowId=GA524/06/1197"^^ . . "lung inflammation; endotoxin; free radicals; antioxidants; nitric oxide"@en . "lung inflammation" . . . " antioxidants" . "We provide evidence that reactive oxygen a nitrogen species (RONS) play a key role in the development of inflammatory reaction induced by endotoxin, an important irritating component of farm dust. Data showed that the endotoxin induced activation of macr"@en . "GA524/06/1197" . "V r\u00E1mci projektu bylo prok\u00E1z\u00E1no, \u017Ee reaktivn\u00ED metabolity kysl\u00EDku a dus\u00EDku (RMKD) hraj\u00ED kl\u00ED\u010Dovou roli v rozvoji z\u00E1n\u011Btliv\u00E9 reakce indukovan\u00E9 endotoxinem, kter\u00FD je v\u00FDznamnou irituj\u00EDc\u00ED slo\u017Ekou prachu vznikaj\u00EDc\u00EDho v zem\u011Bd\u011Blstv\u00ED. V\u00FDsledky uk\u00E1zaly, \u017Ee endotoxin"@cs . "Role voln\u00FDch radik\u00E1l\u016F v regulaci plicn\u00EDho z\u00E1n\u011Btu vyvolan\u00E9ho akutn\u00ED nebo chronickou expozic\u00ED k endotoxinu" . . . " endotoxin" . . . "1"^^ . . . . "0"^^ . .