"8"^^ . . . . "Analyses of the major histocompatibility complex genes (MHC) have been part of projects concerning not only the immune response of organisms to presence of pathogen. The MHC presents a group of genes of the highly polymorphic loci encoding the proteins that bind a peptide fragment derived from the foreign antigen and stimulate an immune response. Recently, the factors driving and maintaining the extensive MHC polymorphism have been questioned. The pathogen-driven balancing selection and MHC-dependent mating preferences leading to increase the offspring resistance present two non-contradictious hypotheses used to explain the great variability of MHC genes. However, the support for the pathogen-mediated selection is still limited and indirect. The aimsof the project will be to investigate the allelic variability of MHC class IIB genes in large range of cyprinid fish belonging to four subfamilies and phylogenetic analyses inferred from the exon 2 and 3. Using the different molecular methods permits to"@en . "The variability and polymorphism of DAB genes of MHC IIB were analyzed in cyprinid fish including the representatives of different subfamilies. The exon 2 sequences were identified as the targets of positive selection (potentially corresponding to the pa"@en . . . . . . "1"^^ . . "1"^^ . . . "2007-10-16+02:00"^^ . . "MHC class IIB genes of European cyprinid fish: their genetic variability and evolution in relation to the host life-history traits and parasitism"@en . . "0"^^ . "MHC t\u0159\u00EDda IIB gen\u016F evropsk\u00FDch kaprovit\u00FDch ryb: jejich genetick\u00E1 variabilita a evoluce ve vztahu k \u017Eivotn\u00ED strategii hostitel\u016F a parazitismu" . "http://www.isvav.cz/projectDetail.do?rowId=GA524/04/1128"^^ . . . "Studium MHC (major histocompatibility komplexu) gen\u016F je sou\u010D\u00E1st\u00ED projekt\u016F zam\u011B\u0159en\u00FDch nejen na studium imunitn\u00ED odpov\u011Bdi organism\u016F na p\u0159\u00EDtomnost antigenu. MHC p\u0159edstavuje skupinu gen\u016F charakteristick\u00FDch p\u0159\u00EDtomnost\u00ED vysoce polymorfn\u00EDch lokus\u016F k\u00F3duj\u00EDc\u00EDch proteiny, kter\u00E9 jsou schopny rozpoznat peptidick\u00FD \u0159et\u011Bzec patogenu a stimuluj\u00ED imunitn\u00ED odpov\u011B\u010F. V sou\u010Dastn\u00E9 dob\u011B jsou \u010Dast\u00FDm p\u0159edm\u011Btem studia faktory vedouc\u00ED k rozs\u00E1hl\u00E9mu polymorfizmu MHC gen\u016F a jeho udr\u017Een\u00ED. Patogenn\u011B \u0159\u00EDzena selekce a nebo selekce zalo\u017Een\u00E1 na preferenc\u00EDch spojen\u00FDch s p\u00E1rov\u00E1n\u00EDm jedinc\u016F a vedouc\u00EDch k zv\u00FD\u0161en\u00ED rezistence u potomstva, p\u0159edstavuj\u00ED dv\u011B ne protich\u016Fdn\u00E9 hypot\u00E9zy, kter\u00E9 mohou vysv\u011Btlit vysokou variabilitu MHC gen\u016F. Ka\u017Edop\u00E1dn\u011B, d\u016Fkazy podporuj\u00EDc\u00ED selekci zprost\u0159edkovanou patogeny jsou limitov\u00E1ny a nep\u0159\u00EDm\u00E9. C\u00EDlem p\u0159edlo\u017Een\u00E9ho projektu je studium variability alel skupiny IIB MHC u \u0161irok\u00E9 \u0161k\u00E1ly kaprovit\u00FDch ryb n\u00E1le\u017Eej\u00EDc\u00EDch do \u010Dty\u0159ech pod\u010Deled\u00ED a fylogenetick\u00E1 anal\u00FDza exonu 2 a 3. Vyu\u017Eit\u00ED r\u016Fzn\u00FDch molekul\u00E1rn\u00EDch metod povede k" . . . . . "Variabilita a polymorfizmus gen\u016F DAB t\u0159\u00EDdy MHC IIB byly analyzov\u00E1ny u kaprovit\u00FDch ryb, z\u00E1stupc\u016F r\u016Fzn\u00FDch pod\u010Deled\u00ED. Potvrzen byl vliv pozitivn\u00ED selekce u sekvenc\u00ED exonu 2 potenci\u00E1ln\u011B zprost\u0159edkovan\u00E9 parazity nebo patogeny, a negativn\u00ED selekci u exonu 3. A"@cs . "GA524/04/1128" . . . "8"^^ . "Neuvedeno."@en .