"P\u0159edm\u011Btem projektu je detekce polymorfismu na \u00FArovni DNA a ur\u010Den\u00ED alelick\u00FDch variant vybran\u00FDch kandid\u00E1tn\u00EDch gen\u016F u prasete. V\u00FDb\u011Br konkr\u00E9tn\u00EDch kandid\u00E1tn\u00EDch gen\u016F ovliv\u0148uj\u00EDc\u00EDch masnou u\u017Eitkovost a reproduk\u010Dn\u00ED vlastnosti bude proveden na z\u00E1klad\u011B aktu\u00E1ln\u00EDho stavu mapov\u00E1n\u00ED genomu prasete, a to z chromozomov\u00FDch oblast\u00ED, ve kter\u00FDch byla prok\u00E1z\u00E1na existence QTL. Specifick\u00E9 \u00FAseky gen\u016F budou izolov\u00E1ny pomoc\u00ED metody polymer\u00E1zov\u00E9 \u0159et\u011Bzov\u00E9 reakce na z\u00E1klad\u011B primer\u016F navr\u017Een\u00FDch podle EMBL datab\u00E1ze u prasete nebo podlehomologi\u00ED s \u00FAseky lidsk\u00E9 nebo my\u0161\u00ED DNA. V t\u011Bchto fragmentech bude vyhled\u00E1v\u00E1n polymorfismus pomoc\u00ED molekul\u00E1rn\u011B genetick\u00FDch metod PCR-RFLP, DGGE, TTGE aj., z nich\u017E n\u011Bkter\u00E9 budou na pracovi\u0161ti nov\u011B zavedeny. Nalezen\u00FD polymorfismus bude testov\u00E1n na populac\u00EDcprasat chov\u016F v \u010CR a hlavn\u011B na zv\u00ED\u0159atech t\u0159ech referen\u010Dn\u00EDch rodin prasat p\u0159ipraven\u00FDch Universitou v Hohenheimu. V\u00FDsledky budou vyu\u017Eiteln\u00E9 pro n\u00E1sledn\u00E9 mapov\u00E1n\u00ED gen\u016F a QTL, v\u00FDpo\u010Dtu genov\u00FDch efekt\u016F a p\u0159isp\u011Bj\u00ED k celkov\u00E9mu pozn\u00E1n\u00ED genomu prasete. To by mohlo" . . . . "Neuvedeno."@en . . "6"^^ . "GA523/99/P043" . . "6"^^ . . . "1"^^ . "http://www.isvav.cz/projectDetail.do?rowId=GA523/99/P043"^^ . "Detekce polymorfismu DNA a kandid\u00E1tn\u00EDch gen\u016F pro u\u017Eitkovost prasat" . . "0"^^ . . "\u0158e\u0161en\u00EDm grantu vzniklo 5 publikac\u00ED (4 vy\u0161ly, 1 p\u0159ijata). Ve 4 p\u0159\u00EDpadech se jedn\u00E1 o Anim. Genet., presti\u017En\u00ED \u010Dasopis v dan\u00E9m oboru. Pr\u00E1ce \u0159e\u0161itele v\u00FDznamn\u011B obohatila navazuj\u00EDc\u00ED grant a p\u0159isp\u011Bla k prohlouben\u00ED znalost\u00ED o genomu prasete. Doporu\u010Dujeme hodnotit"@cs . . "Detection of DNA polymorphism of candidate genes for performance in pigs"@en . "0"^^ . . "The object of the presented project is a detection of DNA polymorphism and a determination of allelic variant of selected candidate genes in pig. The selection of candidate genes influencing meat performance and reproductive traits will be performed on the basis of actual state of pig genome mapping from chromosome areas in which QTL was evidenced. The specific fragments of the genes will be isolated with help of PCR. The primers will be designed according to the EMBL database in pig or by using the homology with fragments of human and mouse DNA. In these fragments the polymorphism will be found with the help of molecular genetics methods PCR-RFLP, DGGE, TGGE, etc. New polymorphism will be tested in pig populations in Czech Republic and in animals from three referent families generated by the Hohenheim University. The results will be applicable to subsequent mapping of genes and QTLs, determination of gene effects and it contribute to knowledge of pig genome. It could have a practical importance f"@en . . . . . . "2003-04-01+02:00"^^ .