. . . . . "http://www.isvav.cz/projectDetail.do?rowId=GA523/96/1738"^^ . . "Podstatou projektu je studium norm\u00E1ln\u00ED a n\u00E1dorov\u011B bun\u011B\u010Dn\u00E9 afinity k bovinn\u00ED semin\u00E1ln\u00ED ribonukle\u00E1ze (BS RN\u00E1se) a jej\u00EDm mutant\u016Fm p\u0159ipraven\u00FDch rekombinantn\u00EDmi technikami. Lidsk\u00E9 n\u00E1dorov\u00E9 bu\u0148ky budou transplantov\u00E1ny nu/nu a AJRI my\u0161\u00EDm a jejich n\u00E1dory injikov\u00E1ny BS RN\u00E1zou a potenci\u00E1ln\u00EDmi protin\u00E1dorov\u00FDmi mutanty. Rovn\u011B\u017E spont\u00E1nn\u00ED melanoblastomov\u00E9 n\u00E1dory prasat budou takto studov\u00E1ny. V p\u0159\u00EDpad\u011B p\u0159\u00EDpravy specifick\u00E9ho imunopresivn\u00EDho mutantu bude tento pou\u017Eit p\u0159i org\u00E1nov\u00FDch a bun\u011B\u010Dn\u00FDch transplantac\u00EDch. Obobn\u011B p\u0159i potvrzen\u00ED p\u0159edb\u011B\u017En\u011B specifick\u00E9 aspermatogenn\u00ED substance bude tato pou\u017Eita v aspermatogenn\u00EDch fenom\u00E9nech zv\u00ED\u0159at. Pl\u00E1novan\u00E9 experimenty pomohou formulovat vztah mezi strukturou katalytickou a biologickou aktivitou BS RN\u00E1zy a jej\u00EDmi molekularn\u00EDmi mutanty." . "0"^^ . . . . "1"^^ . "GA523/96/1738" . . . . . "The purpose of this collaborative project is to prepare various mutants and hybrid preparation of bovine seminal ribonuclease (in Madison), to examine antitumor, immunosuppressive and aspermatogenic activities of these derivatives compared to native BS RNase (in Prague and Lib\u011Bchov) and to formulate hypothesis that relate primary structure and biological activities in RNases based on experimental results (Lib\u011Bchov, Prague, Madison). The obtained results will help us to select the best structure of RNasefor aiming its specific action at individual biological function."@en . "0"^^ . . . "Bovinn\u00ED semin\u00E1ln\u00ED ribonukle\u00E1za (BS RNase) a jej\u00ED rekombinantn\u00ED mutanty v biologick\u00FDch syst\u00E9mech (kancerogeneze, sexu\u00E1ln\u00ED modulace, imunosuprese)" . "13"^^ . "13"^^ . "Projekt je zam\u011B\u0159en na aktu\u00E1ln\u00ED problematiku - poda\u0159ilo se prok\u00E1zat dal\u0161\u00ED dosud nezn\u00E1m\u00E9 biologick\u00E9 \u00FA\u010Dinky BS-Rn\u00E1zy a to zejm\u00E9na na n\u00E1dorov\u00E9 bu\u0148ky. Vysok\u00FD odborn\u00FD p\u0159\u00EDnos je potvrzen p\u0159ijat\u00FDmi publikacemi. \u00DAdaje v z\u00E1v\u011Bre\u010Dn\u00E9 kart\u011B byly dopln\u011Bny a jsou adekv\u00E1"@cs . "Bovine seminal ribonuclease (BS RNase) and its mutants that have biological effecte (cancerostatic, sexual cells modulative and immunosuppressive)"@en .