. "10"^^ . "10"^^ . " polymorphism" . "pig" . "Anal\u00FDza exprese a polymorfismu kandid\u00E1tn\u00EDch gen\u016F reguluj\u00EDc\u00EDch v\u00FDvoj a r\u016Fst sval\u016F prasat" . . "Bylo dokon\u010Deno studium osmi gen\u016F exprimovan\u00FDch ve fet\u00E1ln\u00EDch svalech prasat (FBN2, CNN3, DCN, POSTN, RBM39, GNAS, YWHAQ a SPARC). U t\u011Bchto gen\u016F byly identifikov\u00E1ny polymorfismy, geny byly zmapov\u00E1ny (vazbov\u011B a na RH panelu) a bylo provedeno studium asociac"@cs . . . " candidate genes" . "2008-04-25+02:00"^^ . "V posledn\u00EDch\u00A0letech byly odhaleny\u00A0QTL pro produkci a kvalitu masa u prasat a byla studov\u00E1na \u0159ada gen\u016F s p\u0159edpokl\u00E1dan\u00FDm efektem na tyto znaky. O\u010Dek\u00E1v\u00E1 se, \u017Ee anal\u00FDza t\u011Bchto a dal\u0161\u00EDch gen\u016F, jako\u017E i t\u011Bch, kter\u00E9 jsou exprimov\u00E1ny ve fet\u00E1ln\u00EDch svalech prasat, odhal\u00ED kandid\u00E1tn\u00ED geny pro genetick\u00E9 zlep\u0161ov\u00E1n\u00ED\u00A0masn\u00E9 u\u017Eitkovosti. V ned\u00E1vn\u00E9 dob\u011B jsme zah\u00E1jili studium diferen\u010Dn\u011B exprimovan\u00FDch gen\u016F ve fet\u00E1ln\u00EDch kostern\u00EDch svalech s c\u00EDlem nal\u00E9zt geny a mutace, kter\u00E9 se uplat\u0148uj\u00ED ve v\u00FDvoji sval\u016F. V\u00A0navrhovan\u00E9m projektuse budeme zam\u011B\u0159ovat na: (1) Anal\u00FDzu kandid\u00E1tn\u00EDch gen\u016F ovliv\u0148uj\u00EDc\u00EDch diferenciaci a metabolismus svalov\u00E9 tk\u00E1n\u011B, zalo\u017Een\u00E9 na poznatc\u00EDch z komparativn\u00EDho mapov\u00E1n\u00ED a lokalizace gen\u016F v QTL intervalech t\u0159\u00ED hohenheimsk\u00FDch rodin pou\u017E\u00EDvan\u00FDch pro mapov\u00E1n\u00ED QTL (WxP, MxP a WxM), ve kter\u00FDch budou mapov\u00E1ny nov\u00E9 QTL\u00A0ovliv\u0148uj\u00EDc\u00ED detailn\u00ED znaky svalov\u00FDch vl\u00E1ken (pr\u016Fm\u011Br, po\u010Det, anaerobn\u00ED metabolismus). (2) Dal\u0161\u00ED anal\u00FDzu diferen\u010Dn\u011B exprimovan\u00FDch gen\u016F ve fet\u00E1ln\u00EDch svalech prasete, v\u010Detn\u011B produkce nov\u00E9 fet\u00E1ln\u00ED (50 dn\u016F" . "In recent years numerous QTLs for porcine meat production and\u00A0quality traits have been detected and many genes expected to affect these traits have been studied. Analysis of these and other genes, as well as those expressed in porcine muscles is thought to\u00A0reveal\u00A0candidate genes for genetic improvement of meat production. Recently we have initiated studies of differentially expressed genes in fetal skeletal muscles, with the goal to find genes and mutations playing role in muscle development. In this project\u00A0we will focus on: (1) Analysis of candidate genes involved in differentiation and metabolism of muscle tissue, based on comparative map data\u00A0and located in QTL intervals of three Hohenheim\u00A0families (WxP, MxP and WxM), where QTLs\u00A0affecting new detailed traits of muscle fibres (diameter, number, anaerobic metabolism) will be searched for. (2) Further analysis of differentially expressed genes in porcine fetal skeletal\u00A0muscles, including production of a new fetal (50 days) subtracted cDNA"@en . "2008-12-31+01:00"^^ . " skeletal muscles" . "2009-10-22+02:00"^^ . . . " gene expression" . . . . . . "http://www.isvav.cz/projectDetail.do?rowId=GA523/06/1302"^^ . "GA523/06/1302" . "2006-01-01+01:00"^^ . . "0"^^ . . "The study of eight genes expressed in porcine fetal muscles (FBN2, CNN3, DCN, POSTN, RBM39, GNAS, YWHAQ and SPARC) has been completed. Polymorphisms were identified in the genes, the genes were mapped (by linkage analysis and on the RH panel) and associa"@en . . "1"^^ . . "1"^^ . . . "pig; skeletal muscles; gene expression; polymorphism; candidate genes; EST"@en . . . "Analysis of expression and polymorphism of candidate genes regulating muscle development and growth in pigs"@en .