. "http://www.isvav.cz/projectDetail.do?rowId=GA514/94/0412"^^ . . "GA514/94/0412" . . "Imunosupresivn\u00ED efekt bovinn\u00ED sperm\u00E1ln\u00ED ribonukle\u00E1zy a urokanov\u00E9 kyseliny na modelu rejekce rohovkov\u00E9ho transplant\u00E1tu u kr\u00E1l\u00EDka" . . . . . . "1"^^ . . "1"^^ . "C\u00EDlem navrhovan\u00E9ho projektu je vyu\u017Eit\u00ED experiment\u00E1ln\u00EDho modelu orthotopick\u00E9 transplantace rohovky k testov\u00E1n\u00ED imunosupresivn\u00EDho \u00FA\u010Dinku bovinn\u00ED sperm\u00E1ln\u00ED ribonukle\u00E1zy (BS RN\u00E1za) a cis-urokanov\u00E9 kyseliny. Hodnocen\u00ED \u00FA\u010Dinku l\u00E1tek provedeme na transplant\u00E1techmezi outbredn\u00EDmi kmeny kr\u00E1l\u00EDk\u016F. Model vyu\u017Eijeme ke stanoven\u00ED nejvhodn\u011Bj\u0161\u00ED d\u00E1vky a zp\u016Fsobu pod\u00E1n\u00ED testovan\u00FDch l\u00E1tek. Imunosupresivn\u00ED efekt l\u00E1tek bude srovn\u00E1n s \u00FA\u010Dinkem klinicky pou\u017E\u00EDvan\u00FDch kortikosteroid\u016F. Farmakokinetiku imunosupresiv budeme hodnotit im nochemick\u00FDmi metodami a chromatograficky. Z\u00EDskan\u00E9 poznatky p\u0159isp\u011Bj\u00ED k \u00FAsil\u00ED dos\u00E1hnout vy\u0161\u0161\u00ED \u00FAsp\u011B\u0161nosti p\u0159i orthotopick\u00FDch transplantac\u00EDch rohovky v hum\u00E1nn\u00ED medicin\u011B." . "3"^^ . "Immunosuppressive Effect of Bovine Seminal Fibonucklease and Urocanic Acid in the Rabbit Model of Corneal Transplant Rejection"@en . "3"^^ . . "0"^^ . . .