. . . . . "0"^^ . "2003-04-01+02:00"^^ . "C\u00EDlem \u0159e\u0161en\u00E9ho projektu bylo studium mechanism\u016F, kter\u00E9 by umo\u017Enily realizaci genov\u00E9 terapie n\u00E1dor\u016F vyvolan\u00FDch lidsk\u00FDmi popillomaviry (HPV), kter\u00E9 jsou p\u016Fvodci karcinomu d\u011Blo\u017En\u00EDho \u010D\u00EDpku. Projekt byl zalo\u017Een na experimentech s hlodav\u010D\u00EDmi bu\u0148kami transformo"@cs . "28"^^ . . "C\u00EDlem projektu je roz\u0161\u00ED\u0159it sou\u010Dasn\u00E9 mo\u017Enosti genov\u00E9 terapie n\u00E1dor\u016F vyvolan\u00FDch lidsk\u00FDmi papillomaviry (HPV), kter\u00E9 jsou p\u016Fvodci karcinomu d\u011Blo\u017En\u00EDho \u010D\u00EDpku. K studiu poslou\u017E\u00ED bu\u0148ky Syrsk\u00FDch k\u0159e\u010Dk\u016F a bu\u0148ky my\u0161\u00ED C57BL/6, transformovan\u00E9 virem HPV 16. Tyto bu\u0148ky exprimuj\u00ED virov\u00E9 onkoproteiny E6 a E7. Transformovan\u00E9 bu\u0148ky budou ozna\u010Deny sebevra\u017Eedn\u00FDmi geny a geny pro imunostimula\u010Dn\u00ED faktory a bude posouzena schopnost takto pozm\u011Bn\u011Bn\u00FDch bun\u011Bk vyvolat imunitu k transplantaci rodi\u010Dovsk\u00FDch, nemodifikovan\u00FDch n\u00E1dorov\u00FDch bun\u011Bk a uplatnit se p\u0159i l\u00E9\u010Db\u011B n\u00E1dor\u016F jimi vyvolan\u00FDch. Zvl\u00E1\u0161tn\u00ED pozornost bude v\u011Bnov\u00E1na mo\u017Enostem ovlivnit jev zn\u00E1m\u00FD jako %22by-stander efekt%22 p\u0159edchoz\u00ED imunizac\u00ED. Podstatnou \u010D\u00E1st projektu tvo\u0159\u00ED prov\u011Brka r\u016Fzn\u00FDch typ\u016F podp\u016Frn\u00FDch terapeutick\u00FDch z\u00E1sah\u016F, mezi nimi\u017E v\u00FDznamnou roli budou hr\u00E1t vakciny na basi dendritick\u00FDch bun\u011Bk nesouc\u00EDch imunodominantn\u00ED epitopy onkoprotein\u016F E6 a E7 a mutanty viru herpes simplex s cytologick\u00FDm \u00FA\u010Dinkem na replikuj\u00EDc\u00ED se ale nikoli na nereplikuj\u00EDc\u00ED se bu\u0148ky. Budou zko" . "28"^^ . . "Experimental gene therapy of virus-induced tumours"@en . "1"^^ . . . "GA312/99/0542" . "1"^^ . . . . . "The aim of the project is to expand the contemporary possibilities of therapy of tumours elicited by human papillomaviruses (HPV), which are etiologically involved in cervical carcinoma. Syrian- hamster and C57BL/6-mouse cells transformed by HPV 16 will be used in the study. These cells express the E6 and E7 viral oncoproteins. Transformed cells will be labelled with suicide genes and genes for immunostimulation factors, and the ability of the cells to induce immunity to challenge by unmodified parent tumour cells and to attack tumours produced by the latter cells will be examined. Special attention will be paid to the possibility of influencing the phenomenon known as the %22by-stander effect%22 by antecedent immunization. A substantial part of the project will be devoted to verification of different types of supportive therapeutic interventions, significant roles among which will be played by vaccines based on dentritic cells carrying oncoprotein-E6 and E7 immunodominant epitopes and by herpes sim"@en . "Experiment\u00E1ln\u00ED genov\u00E1 terapie n\u00E1dor\u016F vyvolan\u00FDch viry" . "Neuvedeno."@en . . "http://www.isvav.cz/projectDetail.do?rowId=GA312/99/0542"^^ . .