. "http://www.isvav.cz/projectDetail.do?rowId=GA311/95/1425"^^ . . "Antibodies against antigens in orbital tissue in endocrine orbitopathy before an after elimination of thyroid gland"@en . . . "1"^^ . . "GA311/95/1425" . . . "1"^^ . "0"^^ . . "1"^^ . . "Protil\u00E1tky proti antigen\u016Fm v orbit\u011B u nemocn\u00FDch s endokrinn\u00ED orbitopati\u00ED p\u0159ed a po eliminaci \u0161t\u00EDtn\u00E9 \u017El\u00E1zy" . "0"^^ . . . . "U 23 % nemocn\u00FDch s endokrinn\u00ED orbitopati\u00ED po \u00FApln\u00E9 eliminaci \u0161t\u00EDtn\u00E9 \u017El\u00E1zy byly nalezeny dva roky po eliminaci, \u010Di pozd\u011Bji, protil\u00E1tky proti receptor\u016Fm pro TSH. Zdroj takov\u00FDchto protil\u00E1tek mus\u00ED b\u00FDt extratyreoid\u00E1ln\u00ED. Proto\u017Ee jsou receptory pro TSH p\u0159\u00EDtomnyve fibroblastech orbity a pretibi\u00E1ln\u00EDho myxedenu, jsou pravd\u011Bpodobn\u011B zdrojem t\u011Bchto protil\u00E1tek tk\u00E1n\u011B v orbit\u011B a lo\u017Eiska pretibi\u00E1ln\u00EDho myxedemu. U pacient\u016F dva roky po eliminaci \u0161t\u00EDtn\u00E9 \u017El\u00E1zy, nebo pozd\u011Bji, je p\u0159\u00EDtomnost vy\u0161\u0161\u00EDch hladin protil\u00E1tek proti TS H u\u017Eite\u010Dn\u00FDm sign\u00E1lem imunitn\u00ED orbit\u00E1ln\u00ED aktivity. Je mo\u017Eno o\u010Dek\u00E1vat, \u017Ee budou nalezeny i jin\u00E9 protil\u00E1tky proti orbit\u00E1ln\u00EDm antigen\u016Fm a ty by mohly podobn\u011B slou\u017Eit jako zn\u00E1mky aktivity orbit\u00E1ln\u00EDho procesu. Chceme se pokusit odhalit takov\u00E9to protil\u00E1tky, jejich antigeny a peptidick\u00E9 epitopy a vyvinout novou laboratorn\u00ED metodu k m\u011B\u0159en\u00ED takov\u00FDchto protil\u00E1tek." . . .