. "Proteiny v\u00E1zaj\u00EDc\u00ED v\u00E1pn\u00EDk - biologick\u00E9 znaky malign\u00ED transformace sliznice tlust\u00E9ho st\u0159eva. Rakovina tlust\u00E9ho st\u0159eva zauj\u00EDm\u00E1 v \u010Cesk\u00E9 republice u mu\u017E\u016F prvn\u00ED m\u00EDsto, a to jak v incidenci, tak i v mortalit\u011B. P\u0159es zna\u010Dn\u00E9 pokroky v molekul\u00E1rn\u00ED genetice kolorekt\u00E1ln\u00EDho karcinomu z\u016Fst\u00E1v\u00E1 etiologie tohoto n\u00E1dorov\u00E9ho onemocn\u011Bn\u00ED st\u00E1le nezn\u00E1m\u00E1. Jedn\u00EDm z faktor\u016F, kter\u00FD ovliv\u0148uje proces malign\u00ED transformace tlust\u00E9ho st\u0159eva, je koncentrace v\u00E1pn\u00EDkov\u00FDch iont\u016F ve fek\u00E1ln\u00ED tekutin\u011B. Krom\u011B neutralizace mastn\u00FDch kyselin s dlouh\u00FDm \u0159et\u011Bzcem se p\u0159edpokl\u00E1d\u00E1 i bezprost\u0159edn\u00ED efekt v\u00E1penat\u00FDch iont\u016F na epitelov\u00E9 bu\u0148ky zprost\u0159edkovan\u00FD specifick\u00FDmi membr\u00E1nov\u00FDmi receptory. V\u00E1penat\u00E9 ionty se \u00FA\u010Dastn\u00ED intracelul\u00E1rn\u00ED regulace \u0159ady biologick\u00FDch proces\u016F, a to prost\u0159ednictv\u00EDm interakce s proteiny v\u00E1zaj\u00EDc\u00EDmi v\u00E1pn\u00EDk. Jednou z nejd\u016Fle\u017Eit\u011Bj\u0161\u00EDch funkc\u00ED v\u00E1penat\u00FDch iont\u016F je ovlivn\u011Bn\u00ED nitrobun\u011B\u010Dn\u00FDch sign\u00E1ln\u00EDch mechanizm\u016F, d\u00E1le regulace aktivity \u0159ady enzym\u016F, receptor\u016F, regula\u010Dn\u00EDch a struktur\u00E1ln\u00EDch protein\u016F uvnit\u0159 bu\u0148ky. V sou\u010Dasn\u00E9 dob\u011B se p\u0159edpokl\u00E1d\u00E1" . . . "GA310/98/P238" . "Projekt byl v\u011Bnov\u00E1n velmi z\u00E1va\u017En\u00E9mu a aktu\u00E1ln\u00EDmu t\u00E9matu z\u00E1kladn\u00EDho i klinick\u00E9ho v\u00FDzkumu, anal\u00FDze zm\u011Bn b\u00EDlkovin souvisej\u00EDc\u00EDch s malign\u00ED transformac\u00ED sliznice tlust\u00E9ho st\u0159eva. V n\u00E1vaznosti na v\u00FDzkum garanta projektu byl zam\u011B\u0159en na b\u00EDlkoviny v\u00E1zaj\u00EDc\u00ED v\u00E1pn\u00EDk"@cs . "0"^^ . "Proteiny v\u00E1zaj\u00EDc\u00ED v\u00E1pn\u00EDk - biologick\u00E9 znaky malign\u00ED transformace sliznice tlust\u00E9ho st\u0159eva" . . . . . "http://www.isvav.cz/projectDetail.do?rowId=GA310/98/P238"^^ . "1"^^ . "The colorectal cancer occupies first position both in the incidence and in the mortality in men in Czech Republic.The aetiology of this malignant disorder is still unknown despite of progress in colorectal carcinoma molecular genetic. The Ca2+ ions are suggested to play important role in the colorectal cancer development. Ca2+ ions are involved in the regulation of many different biological processes via interaction with a large number of calcium-binding proteins. One of their most important functions is to act in intracellular signal transduction. Ca2+ can trigger and regulate the activities of a variety of enzymes, receptors, ion channels, regulatory and structural proteins.The S100 calcium-binding proteins recently became of major interest because of their differential expression in neoplastic tissues and involvement in metastatic processes. The aim of this project is the investigation of calcium binding proteins expression in normal colonic tissue, in colonic adenomas and in colorectal carcinomas"@en . . "1"^^ . . "0"^^ . "1"^^ . . "Calcium binding proteins - biological markers of colon mucosa malignant"@en . . . . .