"GA310/98/0083" . "http://www.isvav.cz/projectDetail.do?rowId=GA310/98/0083"^^ . . "Projekt \u0159e\u0161\u00ED problematiku bakteriocin\u016F \u010Deledi Enterobacteriaceae a navazuje na projekty \u0159e\u0161en\u00E9 v p\u0159edchoz\u00EDch letech. Pro \u0159e\u0161en\u00ED projektu byly pou\u017Eity nejnov\u011Bj\u0161\u00ED metody molekul\u00E1rn\u00ED biologie, v\u010Detn\u011B sekvenov\u00E1n\u00ED. Molekul\u00E1rn\u011B biologick\u00E9 charakteristiky bioci"@cs . . . "Bakteriociny \u010Deledi Enterobacteriaceae:v\u00FDskyt, nov\u00E9 typy a molekul\u00E1rn\u00ED biologie" . . "Projekt zahrnuje 6 t\u00E9matick\u00FDch okruh\u016F, kter\u00E9 navrhovatel\u016Fv v\u00FDzkum v posledn\u00EDch letech otev\u0159el. 1) Je nutno zjistit frekvenci bakteriocinogenie mezi kmeny nov\u011B etablovan\u00FDch druh\u016F rodu Escherichia a poddruh\u016F rodu Klebsiella. 2) K bli\u017E\u0161\u00EDmu pochopen\u00ED jednotliv\u00FDch krok\u016F \u00FA\u010Dinku kolicin\u016F E1 - E9 je nutno komplexn\u011B kvantitativn\u011B zpracovat relace mezi jejich vazbou na citlivou populaci bakteri\u00ED a inhibi\u010Dn\u00EDm p\u016Fsoben\u00EDm. 3) Je nutno pro sv\u011Btovou literaturu zpracovat fyzik\u00E1ln\u011B-chemick\u00E9, biologick\u00E9 a molekul\u00E1rn\u011B-genetick\u00E9 parametry nov\u00E9ho typu kolicinu, kolicinu U. 4) Ke srovn\u00E1vac\u00ED anal\u00FDze vazby kolicin\u016F E1, E2 a E3 na jejich vazebn\u00E9 epitopy v receproru BtuB je nutno kvantitativn\u011B analyzovat jej\u00ED modifikace vystaven\u00EDm citliv\u00FDch bakteri\u00ED specifick\u00FDm aminokyselinov\u00FDm \u010Dinidl\u016Fm. 5) Je nutno zpracovat v\u00FDskyt kolicinogenie mezi kmeny Escherichia coli izolovan\u00FDmi z lidsk\u00E9ho st\u0159eva zdrav\u00E9ho a st\u0159eva s rakovinn\u00FDm n\u00E1dorem. 6) Pro rody, v nich\u017E ji\u017E byla \u010Di bude prok\u00E1z\u00E1na produkce %22korpuskul\u00E1rn\u00EDch bakteriocin\u016F" . . . "The project involves 6 topics which have been opened to research by applicants experiments in the last years: 1) research on the incidence of bacteriocinogeny among strains of the newly acknowledged species of Escherichia and subspecies of Klebsiella. 2)for a closer comprehension of successive steps in the action of colicins E1-E9, research on the relation between their binding on susceptible bacteria and their inhibitive action. 3) investigation into physico-chemical, biological and molecular parameterof a new type of colicin, colicin 4. 4) for comparative analysis of binding of colicins E1-E3 onto their respective epitopes in the receptor protein BtuB, quantification of effects of its modifications with specific amino acid reagents. 5) investigation of the incidence of colicinogeny among E. coli strains present in a healthy colon and in a colon with cancer. 6) as, in some genera, a production of %22corpuscular bacteriocins%22 was found by applicant, studies of their ultrastructure and screening of furth"@en . "9"^^ . . "9"^^ . . . "1"^^ . . "0"^^ . . . "Bacteriocins of the family Enterobacteriaceae: incidence, new types and molecular biology"@en . "0"^^ . . .