. . . "6"^^ . " Candida parapsilosis" . "6"^^ . "\u00DAloha aspart\u00E1tov\u00FDch prote\u00E1z v p\u0159\u00EDjmu nutrient\u016F a v pr\u016Fb\u011Bhu hladov\u011Bn\u00ED patogenn\u00EDch kvasinek Candida albicans a Candida parapsilosis" . . "2011-12-31+01:00"^^ . "Opportunistic pathogens of the genus Candida produce secreted aspartic proteinases that act as one of the virulence factors. These enzymes facilitate the pathogen invasion of the host cells and allow microorganisms to utilize host cell proteins as a source of nutrients. While the secreted proteinases of pathogenic Candida spp. have been already studied, almost nothing is known about intracellular aspartic proteinases. They are predicted to play a role in adaptation of Candida spp. to starvation. Interplay of extracellular and intracellular aspartic proteinases is likely to occur when the Candida spp. have to survive in conditions of low nutrient supply. These phenomena have not been studied in detail; however, their description might help to prevent persistent occurrence of Candida spp. on various surface in hospital environment. We will study the role of aspartic proteinases in starvation of C. albicans, C. parapsilosis, C. orthopsilosis and C. metapsilosis. In parallel, we will examine inhibition and structure-function relationships in these enzymes."@en . "C\u00EDlem projektu je anal\u00FDza intracelul\u00E1rn\u00EDch a extracelul\u00E1rn\u00EDch aspart\u00E1tov\u00FDch prote\u00E1z patogenn\u00EDch kvasinek Candida albicans a Candida parapsilosis. Bude zkoum\u00E1na \u00FAloha t\u011Bchto enzym\u016F v p\u0159e\u017E\u00EDv\u00E1n\u00ED kandid v podm\u00EDnk\u00E1ch s omezenou dostupnost\u00ED nutrient\u016F. Bude tak\u00E9 zkoum\u00E1na interakce prote\u00E1z s inhibitory." . . . . "Candida albicans" . "The project gone according to plan both in terms of expertise and in terms of disbursement of funds."@en . . . . . "Role of aspartic proteinases in nutrient acquisition and starvation of pathogenic yeasts Candida albicans and Candida parapsilosis"@en . . . "\u0158e\u0161en\u00ED projektu prob\u011Bhlo podle pl\u00E1nu jak z hlediska odborn\u00E9ho tak i z hlediska \u010Derp\u00E1n\u00ED finan\u010Dn\u00EDch prost\u0159edk\u016F."@cs . "GA310/09/1945" . "2011-04-16+02:00"^^ . "1"^^ . . "2015-03-02+01:00"^^ . "0"^^ . " Candida metapsilosis" . . "0"^^ . "http://www.isvav.cz/projectDetail.do?rowId=GA310/09/1945"^^ . . . " Candida orthopsilosis" . "Candida albicans; Candida parapsilosis; Candida orthopsilosis; Candida metapsilosis; aspart\u00E1tov\u00E1 pro"@en . "2009-01-01+01:00"^^ . .