"The role of intestinal microflora in the pathogenesis of joint disease"@en . "Neuvedeno."@en . . . "GA310/00/1371" . "Odborn\u00FD p\u0159\u00EDnos projektu: Projekt zkoum\u00E1 na my\u0161\u00EDm modelu onemocn\u011Bn\u00ED ankylosuj\u00EDc\u00ED spondylitidou. V hled\u00E1n\u00ED etiologie a patogeneze tohoto onemocn\u011Bn\u00ED se zam\u011B\u0159il na \u00FAlohu st\u0159evn\u00ED mikrofl\u00F3ry p\u0159i vzniku onemocn\u011Bn\u00ED. Zad\u00E1n\u00ED je velmi z\u00E1slu\u017En\u00E9 a cenn\u00E9 t\u00EDm, \u017Ee se p"@cs . . "A role of intestinal microflora and the human HLA-B2702 transgene in mice susceptible to ankylosing enthesopathy (ANKENT), a naturally occuring mouse joint disease, which is an experimental model for human ankylosing spondylitis (AS), will be studied. Wehave already shown that the presence of intestinal microflora is absolutely required for ANKENT development as no disease was observed in susceptible B10.BR males reared under germ-free (GF) conditions, whilst 30% incidence was recorded in their conventional (CV) littermates. The triggering infectious agent, however, remains elusive. The presence of the HLA-B27 transgene in susceptible strains has previously been shown to increase the ANKENT incidence under CV conditions. The aim of this projectis to: 1. show that the presence of microflora is absolutely required in ANKENT pathogenesis also in HLA-B27 transgenic mice. 2. identify ANKENT triggering microbial agent(s). To do so, GF B10.BR males will be associated with potential pathogens."@en . . "5"^^ . "Navrhujeme projekt, ve kter\u00E9m budeme studovat \u00FAlohu mikrob\u016F a HLA-B2702 transgenu p\u0159i vzniku ankylosuj\u00EDc\u00ED enthesopatie (ANKENT), co\u017E je p\u0159irozen\u011B se vyskytuj\u00EDc\u00ED kloubn\u00ED onemocn\u011Bn\u00ED my\u0161\u00ED, pova\u017Eovan\u00E9 za experiment\u00E1ln\u00ED model lidsk\u00E9 ankylosuj\u00EDc\u00ED spondylitidy (AS). Na\u0161e p\u0159edchoz\u00ED v\u00FDsledky potvrzuj\u00ED, \u017Ee krom\u011B pohlav\u00ED a genetick\u00E9ho pozad\u00ED, je p\u0159\u00EDtomnost st\u0159evn\u00ED mikrofl\u00F3ry nezbytnou podm\u00EDnkou ke vzniku ANKENT. Zat\u00EDmco v bezmikrobn\u00EDm (germfree, GF) prost\u0159ed\u00ED nebylo toto onemocn\u011Bn\u00ED nikdy pozorov\u00E1no, 30% GF samc\u016F p\u0159enesen\u00FDch po odstavu do konven\u010Dn\u00EDch (conventional, CV) podm\u00EDnek b\u011Bhem n\u011Bkolika m\u011Bs\u00EDc\u016F onemocn\u00ED. Mikrobi\u00E1ln\u00ED kmeny zodpov\u011Bdn\u00E9 za tento rozd\u00EDl nejsou dosud zn\u00E1my. C\u00EDlem na\u0161eho projektu bude: 1. uk\u00E1zat, \u017Ee p\u0159\u00EDtomnost mikrofl\u00F3ry je absolutn\u011B nezbytn\u00E1 pro vyvol\u00E1n\u00ED ANKENT i u HLA-B27 transgenn\u00EDch my\u0161\u00ED. Za t\u00EDmto \u00FA\u010Delem bude incidence kloubn\u00EDho onemocn\u011Bn\u00ED porovn\u00E1v\u00E1na v GF a CV prost\u0159ed\u00ED. 2. ur\u010Dit slo\u017Eku st\u0159evn\u00ED mikrofl\u00F3ry, kter\u00E1 je odpov\u011Bdn\u00E1 za vyvol\u00E1n\u00ED ANKENT. Proto bude v\u00FDskyt ANKENT sledov\u00E1n u" . "5"^^ . . . . . . . "1"^^ . "2"^^ . . . . . . "2008-05-19+02:00"^^ . "\u00DAloha st\u0159evn\u00ED mikrofl\u00F3ry p\u0159i vzniku kloubn\u00EDho onemocn\u011Bn\u00ED" . . . "http://www.isvav.cz/projectDetail.do?rowId=GA310/00/1371"^^ . . "0"^^ .