"Acoustical signal processing in the neuronal circuits of the auditory system"@en . "2015-03-02+01:00"^^ . "GA309/07/1336" . "19"^^ . "19"^^ . "http://www.isvav.cz/projectDetail.do?rowId=GA309/07/1336"^^ . "0"^^ . . . . "1"^^ . "Zpracov\u00E1n\u00ED akustick\u00E9ho sign\u00E1lu v neuronov\u00FDch okruz\u00EDch sluchov\u00E9ho syst\u00E9mu" . . . . . "0"^^ . "2011-12-31+01:00"^^ . . . . . "2011-04-16+02:00"^^ . . . . "sluchov\u00FD syst\u00E9m" . " behavior\u00E1ln\u00ED testy" . " elektrofyziologie" . . "\u0158e\u0161en\u00ED projektu prob\u011Bhlo v\u00FDte\u010Dn\u011B, jak z hlediska odborn\u00E9ho tak i z hlediska \u010Derp\u00E1n\u00ED finan\u010Dn\u00EDch prost\u0159edk\u016F."@cs . "V\u00EDcekan\u00E1lov\u00FDmi elektrodami budou sn\u00EDm\u00E1ny neuronov\u00E9 odpov\u011Bdi v colliculus inferior, corpus geniculatum mediale, sluchov\u00E9 k\u016F\u0159e a tak\u00E9 v nesluchov\u00FDch struktur\u00E1ch (amygdala) p\u0159i stimulaci komplexn\u00EDmi zvuky ( nap\u0159. vokalizce zv\u00ED\u0159at). V\u00A0behavior\u00E1ln\u00EDch experimentech chceme roz\u0161\u00ED\u0159it na\u0161e dosavadn\u00ED poznatky o lateralizaci funkc\u00ED v\u00A0mozkov\u00FDch hemisf\u00E9r\u00E1ch potkana a upravit tyto metody pro testov\u00E1n\u00ED sluchov\u00FDch funkc\u00ED u geneticky manipulovan\u00FDch my\u0161\u00ED. Elektrofyziologick\u00E9 a behavior\u00E1ln\u00ED experimenty budou kombinov\u00E1ny s\u00A0imunocytochemickou detekc\u00ED inhibi\u010Dn\u00EDch neuron\u016F ve sluchov\u00E9 k\u016F\u0159e hlodavc\u016F (zvl\u00E1\u0161t\u011B neuron\u016F, kter\u00E9 jsou imunopozitivn\u00ED na kalbindin, parvalbumin, kalretinin a glycin) s c\u00EDlem detailn\u00EDho mapov\u00E1n\u00ED sluchov\u00E9 k\u016Fry. Na\u0161e v\u00FDvojov\u00E9 studie budou pokra\u010Dovat v\u00A0pozn\u00E1n\u00ED \u00FAlohy kalbindinu a kalretininu v\u00A0embryon\u00E1ln\u00EDm a \u010Dasn\u00E9m postnat\u00E1ln\u00ED obdob\u00ED v\u00FDvoje sluchov\u00E9ho syst\u00E9mu. Plasticita v\u00A0centr\u00E1ln\u00EDm sluchov\u00E9m syst\u00E9mu bude studov\u00E1na v\u00A0pokusech, v\u00A0nich\u017E budou zv\u00ED\u0159ata chov\u00E1na v obohacen\u00E9m prost\u0159ed\u00ED. V\u00FDsledky p\u0159isp\u011Bj\u00ED k pozn\u00E1n\u00ED mechanizm\u016F zpracov\u00E1n\u00ED komplexn\u00EDch akustick\u00FDch sign\u00E1l\u016F a \u00FAlohy inhibice ve sluchov\u00E9m syst\u00E9mu." . "sluchov\u00FD syst\u00E9m, elektrofyziologie, imunohistochemie, behavior\u00E1ln\u00ED testy, obohacen\u00E9 prost\u0159ed\u00ED"@en . "2007-01-01+01:00"^^ . "The project was excellent, both in terms of expertise and in terms of disbursement of funds."@en . " imunohistochemie" . "The processing of complex acoustical signals (e.g. animal vocalizations)\u00A0 will be analyzed in the inferior colliculus, medial geniculate body and auditory cortex as well as in nonauditory structures (e.g. amygdala) using multichannel microelectrodes. \u00A0In behavioral experiments we will extend our previous knowledge about the lateralization of functions in the cerebral hemispheres of the rat and we will modify these techniques for testing auditory function in genetically manipulated mice. Electrophysiological and behavioral experiments will be combined with immunocytochemical studies of inhibitory neurons in the rodent auditory cortex\u00A0 (particularly those immunopositive for the calbindin, parvalbumin, calretinin and glycine) in order to obtain a real map of the auditory cortex. Our developmental studies aimed at detecting the role of calbindin and calretinin in the embryonal and early postnatal periods of the development of the auditory system will continue. Finally, the plasticity of the central auditory system of animals raised in an enriched environment will be studied. The results will contribute to our understanding of the mechanisms of complex acoustical signal processing and the role of inhibition in auditory system."@en . . . .