"Imunologick\u00E1 aktivita acyklick\u00FDch analog\u016F nukleotidu" . . . . "GA307/94/0964" . . "10"^^ . "http://www.isvav.cz/projectDetail.do?rowId=GA307/94/0964"^^ . . "10"^^ . . . "Z\u00E1m\u011Brem projektu je studium imunomodula\u010Dn\u00EDch \u00FA\u010Dink\u016F acyklick\u00FDch analog\u016F nukleotid\u016F t\u0159\u00ED strukturn\u00EDch typ\u016F: HPMP, PME a PMP-deriv\u00E1t\u016F odvozen\u00FDch od purinov\u00FDch a pyrimidinov\u00FDch baz\u00ED a jejich aza \u010Di deaza analog\u016F. V\u00FDzkum bude zam\u011B\u0159en p\u0159edev\u0161\u00EDm na stanoven\u00ED a objasn\u011Bn\u00ED mechanismu imunobiologick\u00E9 aktivity t\u011Bch l\u00E1tek, kter\u00E9 jsou jako v\u00FDznamn\u00E1 virostatika \u010Di potenci\u00E1ln\u00ED cytostatika p\u0159edm\u011Btem klinick\u00FDch zkou\u0161ek. Testov\u00E1n\u00ED bude prov\u00E1d\u011Bno jak v podm\u00EDnk\u00E1ch in vitro, tak i in vivo a zvl\u00E1\u0161tn\u00ED pozornost bude v\u011Bnov\u00E1na nspecifick\u00FDm imunitn\u00EDm mechanism\u016Fm, kter\u00E9 se uplat\u0148uj\u00ED p\u0159i obran\u011B organismu proti virov\u00FDm, bakteri\u00E1ln\u00EDm a n\u00E1dorov\u00FDm onemocn\u011Bn\u00EDm. Tyto v\u00FDsledky budou korelov\u00E1ny se studiem transportu, mechanismu \u00FA\u010Dinku a dal\u0161\u00EDmi informacemi z\u00EDskan\u00FDmi na spolupracuj\u00EDc\u00EDch intituc\u00EDch v na\u0161\u00ED republice i v laborato\u0159\u00EDch ve sv\u011Bt\u011B, kter\u00E9 se studiem t\u011Bchto l\u00E1tek zab\u00FDvaj\u00ED." . "1"^^ . . "2"^^ . . . . . "0"^^ . "Immunobiological Activity of Acyclic Nucleotide Analogues"@en . .