"GA307/93/1122" . "Anxiolytick\u00E1 a sedativn\u00ED aktivita benzodiazepinov\u00FDch ligand." . . . . "http://www.isvav.cz/projectDetail.do?rowId=GA307/93/1122"^^ . . "XXX"@cs . "Anxiolytic and Sedative Potency of Benzodiazepine Ligands"@en . . "0"^^ . "2"^^ . . "V tomto projektu navrhujeme zji\u0161\u0165ovat d\u00E1vkovou z\u00E1vislost vybran\u00FDch \u017E\u00E1douc\u00EDch a ne\u017E\u00E1douc\u00EDch \u00FA\u010Dink\u016F benzodiazepinov\u00FDch ligand za jednotn\u00FDch podm\u00EDnek s c\u00EDlem z\u00EDskat co nejadekv\u00E1tn\u011Bj\u0161\u00ED podklady pro hodnocen\u00ED molekul\u00E1rn\u00EDch a receptorov\u00FDch mechanism\u016F anxiolytick\u00E9 a sedativn\u00ED aktivity t\u011Bchto l\u00E1tek. Navrhujeme zji\u0161\u0165ovat z\u00E1vislost anxiolytick\u00E9ho a sedativn\u00EDho \u00FA\u010Dinku benzodiazepinov\u00FDch ligand na d\u00E1vce podle ovlivn\u011Bn\u00ED plach\u00E9ho a lokomo\u010Dn\u00EDho chov\u00E1n\u00ED p\u0159i vnitrodruhov\u00E9m konfliktu u my\u0161\u00ED (ve Farmakologick\u00E9m \u00FAstavu 3. F UK, Praha) a zji\u0161\u0165ovat z\u00E1vislost antikonvulzivn\u00EDho a celkov\u011B inhibi\u010Dn\u00EDho \u00FA\u010Dinku benzodiazepinov\u00FDch ligand na d\u00E1vce podle ovlivn\u011Bn\u00ED korov\u00FDch n\u00E1sledn\u00FDch epileptick\u00FDch v\u00FDboj\u016F, motorick\u00FDch projev\u016F p\u0159i n\u00E1sledn\u00FDch v\u00FDboj\u00EDch a motorick\u00FDch projev\u016F po elektrick\u00E9stimulaci sensorimotorick\u00E9 k\u016Fry u krys (ve Fyziologick\u00E9m \u00FAstavu AV \u010CR, Praha). Z\u00EDskan\u00E9 poznatky by mohly p\u0159isp\u011Bt k hled\u00E1n\u00ED \u00FA\u010Dinn\u011Bj\u0161\u00EDch a bezpe\u010Dn\u011Bj\u0161\u00EDch anxiolytik a k pozn\u00E1v\u00E1n\u00ED humor\u00E1ln\u00EDch mechanism\u016F anxiety." . "2"^^ . . . "1"^^ . "1"^^ . . . . . .