. "Benzodiazepiny (BZS) jsou \u010Dasto pod\u00E1v\u00E1ny t\u011Bhotn\u00FDm \u017Een\u00E1m. Stanoven\u00ED mo\u017En\u00FDch rizik pro v\u00FDvoj mozku stoj\u00ED proto v\u00A0pop\u0159ed\u00ED z\u00E1jmu. V\u00FDsledky ojedin\u011Bl\u00FDch experiment\u00E1ln\u00EDch studi\u00ED nazna\u010Duj\u00ED, \u017Ee pod\u00E1v\u00E1n\u00ED BZS v\u00A0\u010Dasn\u00FDch stadi\u00EDch v\u00FDvoje jedince m\u016F\u017Ee trvale ovlivnit n\u011Bkter\u00E9 mozkov\u00E9 funkce. Tento projekt je napl\u00E1nov\u00E1n tak, aby stanovil dlouhodob\u00E9 riziko pod\u00E1v\u00E1n\u00ED BZS potkan\u016Fm 7.-11.den po narozen\u00ED (to odpov\u00EDd\u00E1 lidsk\u00E9mu perinat\u00E1ln\u00EDmu obdob\u00ED) pro funk\u010Dn\u00ED schopnosti, zejm\u00E9na pro soci\u00E1ln\u00ED a emotivn\u00ED chov\u00E1n\u00ED, pam\u011B\u0165 a pro dr\u00E1\u017Edivost korov\u00FDch struktur. Studie objasn\u00ED, zda pod\u00E1n\u00ED BZS, vedouc\u00ED k funk\u010Dn\u00EDm zm\u011Bn\u00E1m, m\u011Bn\u00ED charakter aktivace mozkov\u00FDch syst\u00E9m\u016F, odpov\u011Bdn\u00FDch za jednotliv\u00E9 prvky chov\u00E1n\u00ED \u010Di vznik z\u00E1chvat\u016F, tj. vede k remodelaci funk\u010Dn\u00EDch mozkov\u00FDch okruh\u016F. Bude stanoveno i riziko neurodegenerace vyvolan\u00E9 opakovan\u00FDm pod\u00E1n\u00EDm BZS a mo\u017En\u00E9 funk\u010Dn\u00ED d\u016Fsledky takto vznikl\u00E9ho po\u0161kozen\u00ED. Z\u00EDskan\u00E1 data umo\u017En\u00ED specifikovat zda je p\u0159edpokl\u00E1dan\u00E1 reorganizace funk\u010Dn\u00EDch okruh\u016F odpov\u011Bdn\u00E1 za alterace chov\u00E1n\u00ED a excitability vyvolan\u00E9 \u010Dasnou stimulac\u00ED BZS receptor\u016F.\u00A0" . . . "Benzodiazepines (BZS) are commonly given to pregnant women. Thus, possible unfavorable effects of early exposure to BZS on brain development have been of great concern. Some experimental studies suggest that early BZS exposure can lead to long-term alteration of various brain functions but data on these effects are very limited. Proposed study is designed to characterize long-term risks of functional dysfunctions, specifically alteration of emotional and social behavior, memory, and brain excitability in rats exposed to BZS at postnatal days 7 -11 (corresponding to human perinatal period). Study will elucidate whether functional disturbances seen in BZS-exposed animals are related to the changes in pattern of activation of circuitry underlying individual functions. The ability of early BZS administration to induce neurodegeneration and its possible functional consequences will be also determined. Obtained data will specify changes of functional networks induced by early stimulation of BZS receptors and their role in the alteration of behavioral parameters and seizure susceptibility."@en . . . "Long-term functional consequences of early benzodiazepine exposure in immature rats."@en . . . . . "6"^^ . . "GA305/09/0846" . . "6"^^ . "0"^^ . . . "2015-12-31+01:00"^^ . . "2015-04-23+02:00"^^ . "1"^^ . . . "benzodiazepines immature brain behavioral dysfunction brain excitability c-fos"@en . "http://www.isvav.cz/projectDetail.do?rowId=GA305/09/0846"^^ . . "0"^^ . "Dlouhodob\u00E9 funk\u010Dn\u00ED d\u016Fsledky opakovan\u00E9ho pod\u00E1v\u00E1n\u00ED benzodiazepin\u016F v \u010Dasn\u00FDch stadi\u00EDch postnat\u00E1ln\u00EDho v\u00FDvoje potkana." . "2009-01-01+01:00"^^ . . .