. "soln\u00E1 hypertenze" . "Mechanismy antihypertenzn\u00EDho p\u016Fsoben\u00ED zv\u00FD\u0161en\u00E9ho p\u0159\u00EDjmu drasl\u00EDku u soln\u00E9 hypertenze" . . "http://www.isvav.cz/projectDetail.do?rowId=GA305/09/0336"^^ . "The project gone according to plan both in terms of expertise and in terms of disbursement of funds."@en . . "0"^^ . "2009-01-01+01:00"^^ . . . "soln\u00E1 hypertenze; zv\u00FD\u0161en\u00FD p\u0159\u00EDjem drasl\u00EDku"@en . "1"^^ . . "Mechanisms of antihypertensive action of high potassium intake in salt hypertension"@en . . "2015-03-02+01:00"^^ . "GA305/09/0336" . "\u0158e\u0161en\u00ED projektu prob\u011Bhlo podle pl\u00E1nu jak z hlediska odborn\u00E9ho tak i z hlediska \u010Derp\u00E1n\u00ED finan\u010Dn\u00EDch prost\u0159edk\u016F."@cs . . . . . "17"^^ . . . . "17"^^ . . "2011-12-31+01:00"^^ . "Increased dietary K+ intake belongs to important components of antihypertensive therapy. There are several unresolved questions a) the difference in mechanisms of preventive and therapeutic action of high K+ intake, b) the effect of high K+ intake in salt-sensitive and -resistant animals, c) the effects of high K+ intake in relation to the age and/or hypertension stage. Using rats with salt or genetic hypertension we would like to elucidate 1) mechanisms of age-dependent antihypertensive action of high K+ intake, namely the role of sympathetic nervous system and NO, 2) therapeutic effects of high K+ intake in young and adult rats with established hypertension, 3) role of enhanced superoxide production at normal or high K+ intake, 4) antihypertensive effects of high K+ intake during chronic blockade of NO synthase or NADPH oxidase, and 5) influence of K+ depletion on the activity of various K+ channels involved in the control of smooth muscle tone in resistance vessels. Our results might contribute to the rationalization of antihypertensive therapy in particular forms of hypertension."@en . "2011-04-16+02:00"^^ . . "C\u00EDlem tohoto projektu je objasnit mechanismy v\u011Bkov\u011B z\u00E1visl\u00E9ho preventivn\u00EDho a terapeutick\u00E9ho \u00FA\u010Dinku vysok\u00E9ho p\u0159\u00EDjmu K+ u r\u016Fzn\u00FDch forem hypertenze, se z\u0159etelem k \u00FAloze sympatiku, oxidu dusnat\u00E9ho, nadprodukce superoxid\u016F a vybran\u00FDch drasl\u00EDkov\u00FDch kan\u00E1l\u016F \u00FA\u010Dastn\u00EDc\u00EDch se kontroly tonu odporov\u00FDch c\u00E9v." . . . "0"^^ . .