"0"^^ . . "1"^^ . "Hlavn\u00EDm v\u00FDsledkem \u0159e\u0161en\u00ED projektu je \u0161est \u010Dl\u00E1nk\u016F v impaktovan\u00FDch \u010Dasopisech, kter\u00E9 z r\u016Fzn\u00E9ho \u00FAhlu pohledu studuj\u00ED vliv farmakologicky navozen\u00E9 stimulace adenosinov\u00FDch membr\u00E1nov\u00FDch receptor\u016F jejich agonisty na krvetvorbu, a to u my\u0161\u00ED norm\u00E1ln\u00EDch nebo takov"@cs . . "2"^^ . "The chief result of investigations performed in the project is represented by six articles in journals with impact factor, which study from various angles the effects of pharmacologically induced stimulation of adenosine membrane receptors with their ago"@en . . "2009-10-22+02:00"^^ . "http://www.isvav.cz/projectDetail.do?rowId=GA305/06/0015"^^ . "Interakce stabiln\u00EDch agonist\u016F adenosinov\u00FDch receptor\u016F a granulocyt\u00E1rn\u00EDho kolonie stimuluj\u00EDc\u00EDho faktoru (G-CSF) v krvetvorb\u011B" . "2006-01-01+01:00"^^ . . . . . "Previous findings of the applicants, obtained when solving the projects Nos. 306/93/0051, 306/96/1721, 306/99/0027, and 305/02/0423 granted by GACR, have demonstrated that stimulation of adenosine membrane receptors with their agonists modulates in experiments with mice hematopoietic processes and that these effects are utilizable in the treatment of myelosuppression. In recent years the aplicants have been concentrated on testing the effects of synthetic adenosine analogs, more or less specific for individual subtypes of adenosine receptors, and distinct consequences of their activation in the sense of stimulation or inhibition of proliferation of hematopoietic progenitor cells have been revealed. In the project submitted, efforts of the applicants will be directed \u00A0to employing combined action of granulocyte colony-stimulating factor and selected synthetic adenosine receptor agonists to potentiate hematopoietic recovery in mice exposed to ionizing radiation or cytotoxic drugs."@en . "adenosine receptors; granulocyte colony-stimulating factor; hematopoiesis"@en . . "Interactions of stable adenosine receptor agonists and granulocyte colony-stimulating factor (G-CSF) in hematopoiesis"@en . . . . "2008-04-25+02:00"^^ . . . "GA305/06/0015" . . "P\u016Fvodn\u00ED n\u00E1lezy navrhovatel\u016F tohoto projektu, z\u00EDskan\u00E9 p\u0159i \u0159e\u0161en\u00ED projekt\u016F GA \u010CR 306/93/0051, 306/96/1721, 306/99/0027 a 305/02/0423, prok\u00E1zaly, \u017Ee stimulace adenosinov\u00FDch membr\u00E1nov\u00FDch receptor\u016F jejich agonisty moduluje v experimentu na my\u0161\u00EDch krvetvorn\u00E9 procesy a \u017Ee t\u011Bchto efekt\u016F je mo\u017En\u00E9 vyu\u017E\u00EDt k l\u00E9\u010Db\u011B myelosuprese. V posledn\u00EDch letech byla pozornost navrhovatel\u016F soust\u0159ed\u011Bna na testov\u00E1n\u00ED \u00FA\u010Dink\u016F syntetick\u00FDch adenosinov\u00FDch analog\u016F, v\u00EDce \u010Di m\u00E9n\u011B specifick\u00FDch pro jednotliv\u00E9 subtypy adenosinov\u00FDch receptor\u016F,a byly odhaleny rozd\u00EDln\u00E9 d\u016Fsledky jejich aktivace ve smyslu stimulace \u010Di inhibice proliferace krvetvorn\u00FDch progenitorov\u00FDch bun\u011Bk. V p\u0159edkl\u00E1dan\u00E9m projektu bude \u00FAsil\u00ED navrhovatel\u016F sm\u011Brov\u00E1no k vyu\u017Eit\u00ED kombinovan\u00E9ho p\u016Fsoben\u00ED vybran\u00FDch syntetick\u00FDch agonist\u016F adenosinov\u00FDch receptor\u016F a granulocyt\u00E1rn\u00EDho kolonie stimuluj\u00EDc\u00EDho faktoru\u00A0 k potenciaci \u00FApravy krvetvorby, po\u0161kozen\u00E9 expozic\u00ED ionizuj\u00EDc\u00EDmu\u00A0 z\u00E1\u0159en\u00ED nebo cytostatik\u016Fm. V\u00FDsledky mohou nal\u00E9zt uplatn\u011Bn\u00ED v praxi p\u0159i l\u00E9\u010Db\u011B myelosupres\u00EDvn\u00EDch stav\u016F." . . "8"^^ . . . "8"^^ . "adenosine receptors" . "2008-12-31+01:00"^^ . . . " granulocyte colony-stimulating factor" .