. "1"^^ . . . "Apoptotick\u00E9 po\u0161kozen\u00ED jater: mo\u017Enosti farmakologick\u00E9ho z\u00E1sahu a potenci\u00E1ln\u00ED v\u00FDznam v hepatoprotekci" . "0"^^ . "2008-12-16+01:00"^^ . . "hepatocytes; intracellular calcium; apoptosis; nitric oxide; free radicals"@en . . . . "2007-05-02+02:00"^^ . "Apoptotic liver injury: possible pharmacological intervention and potential implications in hepatoprotection"@en . . " intracellular calcium" . " apoptosis" . "Ireverzibiln\u00ED otev\u00EDr\u00E1n\u00ED p\u00F3r\u016F pro permeabilitn\u00ED tranzici v hepatocytech, vedouc\u00ED k uvoln\u011Bn\u00ED obsahu mitochondri\u00E1ln\u00ED matrix, v\u010Detn\u011B Ca2+m, by mohlo p\u0159isp\u00EDvat ke zv\u00FD\u0161en\u00ED cytozolov\u00E9ho v\u00E1pn\u00EDku (Ca2+c). Na z\u00E1klad\u011B mnoha experiment\u016F proveden\u00FDch v r\u016Fzn\u00FDch v\u00FDzkumn\u00FDch sm\u011Brech existuj\u00ED dnes d\u016Fkazy, \u017Ee zm\u011Bny bun\u011B\u010Dn\u00E9ho v\u00E1pn\u00EDku jsou spojeny s apoptickou signalizac\u00ED. Jin\u00FDm d\u016Fle\u017Eit\u00FDm sign\u00E1lem, kter\u00FD hraje \u00FAlohu p\u0159i apopt\u00F3ze, je oxid dusnat\u00FD jako v\u00FDsledek \u010Detn\u00FDch potenci\u00E1ln\u00EDch interakc\u00ED s dal\u0161\u00EDmi molekulami, kter\u00FDmi jsou reaktivn\u00ED formy kysl\u00EDku (ROS), ionty kov\u016F a proteiny. Farmakologick\u00E9 p\u0159\u00EDstupy k ochran\u011B hepatocyt\u016F b\u011Bhem apopt\u00F3zy jsou dosud hypotetick\u00E9. Smyslem tohoto v\u00FDzkumn\u00E9ho navrhuje ur\u010Dit vztahy mezi studovan\u00FDmi apoptotick\u00FDmi sign\u00E1ly a jejich modulac\u00ED pomoc\u00ED farmakologick\u00FDch l\u00E1tek v kultu\u0159e hepatocyt\u016F a za podm\u00EDnek in vivo.Tento v\u00FDzkumn\u00FD n\u00E1vrh, podlo\u017Een\u00FD publikovan\u00FDmi daty a p\u0159edb\u011B\u017En\u00FDmi v\u00FDsledky spolu s navr\u017Een\u00FDmi experimenty, nab\u00EDz\u00ED jedine\u010Dnou p\u0159\u00EDle\u017Eitost z\u00EDskat nov\u00FD pohled na d\u016Fle\u017Eitou a" . . . . " nitric oxide" . "In hepatocytes, irreversible opening of permeability transition pore, leading to a release of mitochondrial matrix contents, including Ca2+m could contribute to an increase in cytosolic calcium, (Ca2+c). Several lines of evidence suggest that a change incellular calcium handling is associated with apoptotic signaling. Other important signal, which plays a role in apoptosis, is nitric oxide as a consequence of its numerous potential interactions with other molecules such as reactive oxygen species (ROS),metal ions, and proteins. Pharmacological approaches to prevent hepatocyte loss during apoptosis, so far is hypothetical. The objective of this research proposal is to establish interrelations between studied apoptotic signals and modulation by pharmacological tools in hepatocyte culture and in vivo. The reported data, preliminary results on which this proposal is based and the experiments proposed offer an opportunity to gain new insights as to the important and yet ambiguous role of defined"@en . . "2005-01-01+01:00"^^ . . "The goals of this project were fulfilled. These include the investigation of certain xenobiotic-induced apoptoticsignals and the role played by nitric oxide and calcium in inducing hepatocyte apoptosis and damage likelipopolysaccharide/D-galactosamine, t"@en . . "P\u0159i \u0159e\u0161en\u00ED projektu byly napln\u011Bny v\u0161echny jeho c\u00EDle, tj. studovat apoptotick\u00E9 sign\u00E1ly indukovan\u00E9 ur\u010Dit\u00FDmi xenobiotiky a vliv NO (oxid dusnat\u00FD) na modulaci hepatocyt\u00E1rn\u00ED apopt\u00F3zy ve vztahu k Ca2+ a mitochondri\u00E1ln\u00EDmu potenci\u00E1lu. V\u00FDsledky uk\u00E1zaly, \u017Ee doch\u00E1z"@cs . . . "6"^^ . . "GA305/05/2425" . "6"^^ . "hepatocytes" . "2007-12-31+01:00"^^ . . "http://www.isvav.cz/projectDetail.do?rowId=GA305/05/2425"^^ . "1"^^ . .