"2007-05-02+02:00"^^ . "2008-12-16+01:00"^^ . "Protin\u00E1dorov\u00E1 \u00FA\u010Dinnost \u0159ady koordina\u010Dn\u00EDch komplex\u016F p\u0159echodov\u00FDch kov\u016F je podm\u00EDn\u011Bna jejich schopnost\u00ED po\u0161kodit DNA. V\u00FDsledky z\u00EDskan\u00E9 p\u0159i \u0159e\u0161en\u00ED tohoto projektu p\u0159esv\u011Bd\u010Div\u011B ukazuj\u00ED, \u017Ee modifikace vazby slou\u010Denin odvozen\u00FDch od komplex\u016F kov\u016F, zejm\u00E9na platiny"@cs . "http://www.isvav.cz/projectDetail.do?rowId=GA305/05/2030"^^ . " transition metals" . " ultrasound" . "39"^^ . . "39"^^ . . "2007-12-31+01:00"^^ . . . . . . . "antitumor drugs" . . . "The anticancer activity of several transition metal-based coordination complexes arises from their ability to damage DNA. The results of this project demonstrate convincingly that modification of DNA binding of metal-based compounds, namely platinum and"@en . "1"^^ . . . "1"^^ . . . "2005-01-01+01:00"^^ . "The limitations associated with the clinical use of transition-metal compounds in cancer chemotherapy prompted a search for more effective and less toxic alternativi metal-based antitumor agents. This effort led to the synthesis of thousands of metal-based complexes which were evaluated as antitumor agents and tested in cancer cells, but only several reached clinical trials and most of them have already been rejected. Therefore, the search for new metal-based antitumor drugs and their clinical testing continues to yield more significant improvements in cancer treatment than during last three decades. Broadening the chemotherapeutic arsenal depends on understanding existing agents with a view toward developing new modes of attack. In addition, it is generally accepted that the anticancer activity of several transition metal-based coordination complexes arises from their ability to damage DNA. Hence, the overall significance of this proposal is to ask the fundamental question - can modif\u00EDcation"@en . "0"^^ . "Omezen\u00ED souvisej\u00EDc\u00ED s klinick\u00FDm vyu\u017Eit\u00EDm slou\u010Denin p\u0159echodov\u00FDch kov\u016F v chemoterapii rakoviny byla podn\u011Btem pro vyhled\u00E1v\u00E1n\u00ED efektivn\u011Bj\u0161\u00EDch a m\u00E9n\u011B toxick\u00FDch alternativn\u00EDch cytostatik odvozen\u00FDch od komplex\u016F kov\u016F. Toto \u00FAsil\u00ED ji\u017E vedlo k synt\u00E9ze n\u011Bkolika tis\u00EDc\u016F slou\u010Denin t\u00E9to t\u0159\u00EDdy, kter\u00E9 sice vykazovaly protin\u00E1dorovou \u00FA\u010Dinnost a byly testov\u00E1ny v n\u00E1dorov\u00FDch bu\u0148k\u00E1ch, av\u0161ak pouze n\u011Bkolik z nich bylo posl\u00E9ze klinicky testov\u00E1no a v\u011Bt\u0161ina z nich ji\u017E byla odm\u00EDtnuta. Proto vyhled\u00E1v\u00E1n\u00ED a v\u00FDzkum nov\u00FDch cytostatikodvozen\u00FDch od komplex\u016F kov\u016F a jejich klinick\u00E9 testov\u00E1n\u00ED pokra\u010Duje s c\u00EDlem dos\u00E1hnout v\u00FDrazn\u011Bj\u0161\u00EDho pokroku v l\u00E9\u010Den\u00ED rakoviny. Roz\u0161\u00ED\u0159en\u00ED mo\u017Enost\u00ED pro chemoterapii z\u00E1vis\u00ED na porozum\u011Bn\u00ED biologick\u00FDm \u00FA\u010Dink\u016Fm l\u00E9\u010Div ji\u017E vyu\u017E\u00EDvan\u00FDch v klinick\u00E9 praxi s v\u00FDhledem nal\u00E9zt nov\u00E9 rysy jejich biologick\u00E9ho p\u016Fsoben\u00ED. Krom\u011B toho je v\u0161eobecn\u011B uzn\u00E1vanou skute\u010Dnost\u00ED, \u017Ee protin\u00E1dorov\u00E1 \u00FA\u010Dinnost \u0159ady koordina\u010Dn\u00EDch komplex\u016F p\u0159echodov\u00FDch kov\u016F je podm\u00EDn\u011Bna jejich schopnost\u00ED po\u0161kodit DNA. Obecn\u00FDm c\u00EDlem tohoto navrhuje tedy" . "GA305/05/2030" . . "New approaches to cancer chemotherapy by metal-based drugs"@en . . . . "Nov\u00E9 p\u0159\u00EDstupy k chemoterapii rakoviny l\u00E1tkami odvozen\u00FDmi od slou\u010Denin kov\u016F" . . . "antitumor drugs; transition metals; ultrasound; repair"@en .