. "2007-12-31+01:00"^^ . . . "1"^^ . "1"^^ . . . "Two vascular beds specialized for O2 delivery into the organism, pulmonary and fetoplacental, share many similarities, yet their responses to pathogenetic stimuli, such as chronic hypoxia, have never been compared and are poorly understood. Chronic hypoxic pulmonary hypertension (PHT) is a complication of cardiovascular and pulmonary disorders. This project targets the unknown mechanism of transition from the initial, progressive phase into a stable hypoxic PHT. Its understanding should aid in future management of clinical, continuously progressive PHT. Based on the limited data available so far, we will focus on the roles of reactive oxygen species, nitric oxide, and their influence on extracellular matrix metabolism and interactions with vascular smooth muscle. Right ventricle changes, parallel to the development of PHT, will also be a. Factors responsible for individual variability in PHT, specifically perinatal hypoxia, will also be studied. As the main cause of perinatal hypoxia is"@en . "Pulmonary hypertension; Hypoxia; Placenta; NO; oxidative stress; Metalloproteinases"@en . "Dynamika a mechanismy zm\u011Bn plicn\u00ED a placent\u00E1rn\u00ED cirkulace p\u0159i chronick\u00E9 hypoxii" . "0"^^ . "2008-12-16+01:00"^^ . "GA305/05/0672" . " oxidative stress" . . . "http://www.isvav.cz/projectDetail.do?rowId=GA305/05/0672"^^ . . "Dv\u011B c\u00E9vn\u00ED \u0159e\u010Di\u0161t\u011B, specializovan\u00E1 na dod\u00E1vku O2 do organismu, toti\u017E plicn\u00ED a fetoplacent\u00E1rn\u00ED, se v mnoh\u00E9m podobaj\u00ED, av\u0161ak jejich odpov\u011Bdi na patogenn\u00ED podn\u011Bty (nap\u0159. chronickou hypoxii) nebyly nikdy porovn\u00E1ny a jsou pom\u011Brn\u011B nejasn\u00E9. Chronick\u00E1 hypoxick\u00E1 plicn\u00ED hypertenze (PHT) komplikuje \u0159adu kardiovaskul\u00E1rn\u00EDch a plicn\u00EDch nemoc\u00ED. Tento projekt je zam\u011B\u0159en na nezn\u00E1m\u00FD mechanismus p\u0159echodu hypoxick\u00E9 PHT z po\u010D\u00E1te\u010Dn\u00ED progresivn\u00ED do n\u00E1sledn\u00E9 stabiln\u00ED f\u00E1ze. Jeho pochopen\u00ED by m\u011Blo v budoucnu napomoci klinick\u00E9mu zvl\u00E1d\u00E1n\u00ED trvale progresivn\u00ED klinick\u00E9 PHT. Na z\u00E1klad\u011B omezen\u00FDch \u00FAdaj\u016F. kter\u00E9 jsou zat\u00EDm k dispozici, se zam\u011B\u0159\u00EDme na \u00FAlohu kysl\u00EDkov\u00FDch radik\u00E1l\u016F, oxidu dusnat\u00E9ho a jejich vlivu na metabolismus extracelul\u00E1rn\u00ED matrix a jej\u00ED interakce s c\u00E9vn\u00EDm hladk\u00FDm svalem. Budeme t\u00E9\u017E analyzovat zm\u011Bny prav\u00E9 komory sleduj\u00EDc\u00ED rozvoj PHT. Zam\u011B\u0159\u00EDme se i na faktory podmi\u0148uj\u00EDc\u00ED individu\u00E1ln\u00ED n\u00E1chylnost k PHT, konkr\u00E9tn\u011B na perinat\u00E1ln\u00ED hypoxii. Proto\u017Ee podstatnou p\u0159\u00ED\u010Dinou perinat\u00E1ln\u00ED hypoxie je selh\u00E1n\u00ED transportu plyn\u016F v placent\u011B," . "Dynamics and mechanisms of the chronic hypoxia-induced alterations in pulmonary and placental circulations"@en . "11"^^ . "Chronic hypoxic pulmonary hypertension is a serious complication of chronic lung diseases with respiratory failure in children and adults and occurs also in high altitude residents. It is caused by vasoconstriction and by structural remodelling of periph"@en . "11"^^ . . . . . . " Placenta" . " NO" . "2005-01-01+01:00"^^ . . . . "Chronick\u00E1 hypoxick\u00E1 plicn\u00ED hypertenze je z\u00E1va\u017Enou komplikac\u00ED chronick\u00FDch plicn\u00EDch onemocn\u011Bn\u00ED s respira\u010Dn\u00EDm selh\u00E1n\u00EDm d\u011Bt\u00ED i dosp\u011Bl\u00FDch. Vyskytuje se t\u00E9\u017E p\u0159i pobytu ve vysok\u00E9 nadmo\u0159sk\u00E9 v\u00FD\u0161ce. Je p\u016Fsobena vazokonstrikc\u00ED a p\u0159estavbou struktury perifern\u00EDch pli"@cs . . " Hypoxia" . . "2007-05-02+02:00"^^ . . "Pulmonary hypertension" .