"Neuvedeno."@en . "Pro nespln\u011Bn\u00ED pl\u00E1novan\u00FDch prac\u00ED, ne\u010Derp\u00E1n\u00ED p\u0159id\u011Blen\u00FDch financ\u00ED a odjezdu hlavn\u00EDho \u0159e\u0161itele do zahrani\u010D\u00ED doporu\u010Dila oborov\u00E1 komise l\u00E9ka\u0159sk\u00FDch v\u011Bd tento dvoulet\u00FD projekt p\u0159ed\u010Dasn\u011B ukon\u010Dit."@cs . "1"^^ . "Radiofrequency ablation of the AV node is a therapeutic procedure resulting in complete heart block. It is usually used in patients with otherwise intractable supraventricular tachycardia, predominantly atrial fibrillation with rapid ventricular responseBriefly, the procedure consists of destruction of the AV nodal tissue by a tip of a catheter which can be heated by radiofrequency current. This leads to a formation of a small necrosis. The procedure requires subsequent pacemaker implantation and usuallresults in a dramatic improvement of the symptoms. However, several reports of cardiac arrest or sudden cardiac death within a few days of the procedure have been published. When documented, the ECG showed a rapid polymorphic ventricular tachycardia knowas torsade de pointes, which is a characteristic manifestation of impaired myocardial repolarization (acquired or congenital long QT syndrome). The focus of this research proposal is the study of the possible repolarization impairment immediately"@en . "0"^^ . "Radiofrekven\u010Dn\u00ED ablace AV uzlu je l\u00E9\u010Debn\u00FD v\u00FDkon, jeho\u017E c\u00EDlem je vytvo\u0159en\u00ED kompletn\u00ED AV blok\u00E1dy. Tento postup se pou\u017E\u00EDv\u00E1 u pacient\u016F, kte\u0159\u00ED trp\u00ED jinak ne\u0159e\u0161iteln\u00FDmi formami supraventrikul\u00E1m\u00ED tachykardie, nej\u010Dast\u011Bji fibrilac\u00ED s\u00EDn\u00ED s rychlou komorovou odpov\u011Bd\u00ED. Jeho podstatou je zni\u010Den\u00ED tk\u00E1n\u011B AV uzlu katetrem, jeho\u017E hrot lze zah\u0159\u00E1t aplikac\u00ED radiofrekven\u010Dn\u00EDho proudu, co\u017E vede k vytvo\u0159en\u00ED drobn\u00E9 nekr\u00F3zy. Tento v\u00FDkon vy\u017Eaduje n\u00E1slednou implantaci trval\u00E9ho kardiostimul\u00E1toru a vede zpravidla k dramatick\u00E9mu\u00FAstupu obt\u00ED\u017E\u00ED. \u0158ada autor\u016F v\u0161ak popsala p\u0159\u00EDpady srde\u010Dn\u00ED z\u00E1stavy a n\u00E1hl\u00E9 smrti v odstupu n\u011Bkolika dn\u00ED po tomto v\u00FDkonu. Ty byly v dokumentovan\u00FDch p\u0159\u00EDpadech zp\u016Fsobeny rychlou polymorfn\u00ED komorovou tachykardi\u00ED typu torsade de pointes, kter\u00E1 je jinak charakteristick\u00FDm projevem poruch repolarizace srde\u010Dn\u00EDho svalu (z\u00EDskan\u00FD nebo vrozen\u00FD syndrom prodlou\u017Een\u00E9ho QT intervalu). Smyslem navrhovan\u00E9ho projektu je v\u00FDzkum mo\u017En\u00FDch poruch repolarizace t\u011Bsn\u011B po radiofrekven\u010Dn\u00ED ablaci AV uzlu. Repolarizace bude" . "0"^^ . . . . "0"^^ . . . "Repolarization of ventricular myocardium in patients with atrial fibrillation and chronic tychycardia - mechanism of sudden death after radiofr. ablat. AV node."@en . "http://www.isvav.cz/projectDetail.do?rowId=GA305/02/1253"^^ . "GA305/02/1253" . . . . "Repolarizace myokardu srde\u010Dn\u00ED komory u pacient\u016F s fibrilac\u00ED s\u00EDn\u00ED a chronickou tachykardi\u00ED - mechanizmus n\u00E1hl\u00E9 smrti po radiofrekven\u010Dn\u00ED ablaci AV uzlu" . . . "2008-05-19+02:00"^^ . "0"^^ . . . . . . .