. . "Small lung regions may be insufficiently ventilated, especially in lung disease. If these areas were perfused with blood normaly, this blood would not get oxygenated and after mixing with the rest of the blood returning from the lung into the heart it would cause a decrease in the overall blood oxygenation. This is prevented by a local vasoconstriction in the hypoventilated (and therefore hypoxic) lung areas, which diverts blood flow towards better ventilated lung regions. The mechanism of this so called hypoxic pulmonary vasoconstriction is unknown despite its paramount importance in oxygen delivery to the tissues in health and disease. One likely - and so far little studied - part of the mechanism of hypoxic pulmonary vasoconstriction is the release of calcium from the intracellular stores in the sarcoplasmic reticulum. We propose to use isolated perfused rat lungs and pharmacological tools for perturbing the sarcoplasmic reticulum calcium homeostasis to find out the role of the sarcoplasmic"@en . "Neuvedeno."@en . . . . . . "GA305/00/1432" . "V\u0161echny oblasti plic nemus\u00ED b\u00FDt v\u017Edy perfektn\u011B ventilov\u00E1ny, zejm\u00E9na p\u0159i r\u016Fzn\u00FDch plicn\u00EDch onemocn\u011Bn\u00EDch. Jsou-li tyto \u0161patn\u011B ventilovan\u00E9 oblasti norm\u00E1ln\u011B perfundov\u00E1ny, nem\u016F\u017Ee b\u00FDt krev jimi prot\u00E9kaj\u00EDc\u00ED okysli\u010Dena a po sm\u00EDsen\u00ED se zbytkem krve, kter\u00E1 se vrac\u00EDz plic do srdce, vytv\u00E1\u0159\u00ED ven\u00F3zn\u00ED p\u0159\u00EDm\u011Bs. Ta sni\u017Euje celkov\u00E9 okysli\u010Den\u00ED krve. Tomu br\u00E1n\u00ED lok\u00E1ln\u00ED vasokonstrikce c\u00E9v v hypoventilovan\u00FDch ( a tedy hypoxick\u00FDch) oblastech plic. T\u00EDm doch\u00E1z\u00ED k odklonu krevn\u00EDho pr\u016Ftoku do l\u00E9pe ventilovan\u00FDch plicn\u00EDch oblast\u00ED. Mechanismus t\u00E9to tzv. hypoxick\u00E9 plicn\u00ED vazokonstrikce nen\u00ED zn\u00E1m, navzdory tomu, \u017Ee se jedn\u00E1 o kl\u00ED\u010Dov\u00FD regula\u010Dn\u00ED mechanismus transportu kysl\u00EDku ke tk\u00E1n\u00EDm jak ve zdrav\u00ED, tak i v nemoci. Pravd\u011Bpodobn\u011B a dosud m\u00E1lo studovanou sou\u010D\u00E1st\u00ED mechanismu hypoxick\u00E9 plicn\u00ED vazokonstrikce je uvol\u0148ov\u00E1n\u00ED v\u00E1pn\u00EDku z intracelul\u00E1rn\u00EDch z\u00E1sob v sarkoplasmatick\u00E9m retikulu. Navrhujeme pou\u017E\u00EDt prepar\u00E1t izolovan\u00FDch plic potkana a farmakologick\u00E9 n\u00E1stroje studia intracelul\u00E1rn\u00ED v\u00E1pn\u00EDkov\u00E9 homeost\u00E1zy ke zji\u0161t\u011Bn\u00ED \u00FAlohy" . . . . . . . "0"^^ . "Uvol\u0148ov\u00E1n\u00ED v\u00E1pn\u00EDku ze sarkoplasmatick\u00E9ho retikula:\u00FAloha v regulaci plicn\u00ED cirkulace p\u0159i hypoxii" . "V\u00FDsledky t\u00FDkaj\u00EDc\u00ED se \u00FAlohy drasl\u00EDkov\u00FDch kan\u00E1l\u016F a zm\u011Bn nitrobun\u011B\u010Dn\u00E9ho kalciov\u00E9ho metabolismu v patogenezi plicn\u00ED vasokonstrikce vyvolan\u00E9 hypoxi\u00ED p\u0159edstavuj\u00ED velmi v\u00FDznamn\u00E9 origin\u00E1ln\u00ED n\u00E1lezy. Spolu s v\u00FDjime\u010Dnou publika\u010Dn\u00ED aktivitou opodstat\u0148uj\u00ED celkov\u011B vyn"@cs . . "0"^^ . "http://www.isvav.cz/projectDetail.do?rowId=GA305/00/1432"^^ . "2008-05-19+02:00"^^ . "Calcium release from the sarcoplasmic reticulum in the regulation of the pulmonary circulation during hypoxia"@en . "1"^^ . . "12"^^ . . "12"^^ . . .