. "1"^^ . . . "\u017Delezo hraje kl\u00ED\u010Dovou roli p\u0159i tvorb\u011B kysl\u00EDkov\u00FDch radik\u00E1l\u016F pova\u017Eovan\u00FDch za rozhoduj\u00EDc\u00ED faktor p\u0159i \u0159ad\u011B patologick\u00FDch stav\u016F v\u010Detn\u011B antracyklinov\u00E9 kardiomyopatie. Mezi velmi \u00FA\u010Dinn\u00E9 nov\u00E9 ligandy \u017Eeleza pat\u0159\u00ED deriv\u00E1ty pyridoxalisonicotinoyl hydrazonu (PIH), vyvinut\u00E9 Ponkou. Jedn\u00E1 se o lipofiln\u00ED, intracelul\u00E1rn\u011B prostupuj\u00EDc\u00ED l\u00E1tky s vysokou \u017Eelezochelatuj\u00EDc\u00ED aktivitou, n\u00EDzkou toxicitou, \u00FA\u010Dinn\u00E9 t\u00E9\u017E po p.o. aplikaci. Vzhledem k jejich schopnosti v\u00FDrazn\u011B omezit tvorbu hydroxylov\u00FDch radik\u00E1l\u016F je racion\u00E1ln\u00ED p\u0159edpoklad jejich u\u017Eit\u00ED p\u0159i l\u00E9\u010Db\u011B po\u0161kozen\u00ED tk\u00E1n\u00ED t\u011Bmito radik\u00E1ly. Z hlediska \u0159ady mo\u017En\u00FDch indikac\u00ED t\u011Bchto l\u00E1tek jsou poznatky o jejich vlivu na kardiovaskul\u00E1rn\u00ED syst\u00E9m a na biotransforma\u010Dn\u00ED mechanismy esenci\u00E1ln\u00ED. C\u00EDlem projektu je: - studium vlivu PIH ajeho deriv\u00E1t\u016F na biotransforma\u010Dn\u00ED mechanismy in vivo a in vitro v\u010Detn\u011B mezidruhov\u00E9ho srovn\u00E1n\u00ED u experiment\u00E1ln\u00EDch zv\u00ED\u0159at, - studium jejich kardiotropn\u00EDho a kardiovas- kul\u00E1rn\u00EDho p\u016Fsoben\u00ED (echografick\u00E9 parametry funkce lev\u00E9 komory srde\u010Dn\u00ED /ejek\u010Dn\u00ED frakce," . "1"^^ . . . . "2008-05-19+02:00"^^ . . . "New iron chelators - problems of their cardiovascular, potential cardioprotective and biotransformation effects"@en . . . "0"^^ . . . "GA305/00/0365" . "26"^^ . . "26"^^ . "Neuvedeno."@en . . . . . "Iron plays a key role in the in vivo formation of oxyradicals, which are considered to be the main factor in the etiology of many pathologies incl. anthracycline cardiomyopathy. Pyridoxal isonicotinoyl hydrazone (PIH) and its analogs (developed by Ponka)belong among new effective Fe-chelating agents. These lipophilic substances cross biological membranes -they posses high Fe chelating efficiancy, relativly low toxicity and are highly effective after oral administration. As these substances can significantly inhibit iron-induced generation of oxyradicals, the possibility for their use in the treatment of free radical-caused tissue damage is well-founded. From the viewpoint of a num,ber of therapeutic indications of the drugs, the knowledge of their influence on biotransformation and cardiovascular syst\u00E9m are essential. The project is aimed to: - investigation of the effect of PIH and its derivatives on the mechanisms of biotransformation in vivo and in vitro incl. interspecies comparison in"@en . . "Auto\u0159i vhodn\u00FDmi metodami a modely zkoumali \u00FA\u010Dinky chel\u00E1totvorn\u00FDch l\u00E1tek, kter\u00E9 v\u00E1\u017Eou ionty \u017Eeleza a jsou potenci\u00E1ln\u011B pou\u017Eiteln\u00E9 p\u0159i chorobn\u00FDch stavech doprov\u00E1zen\u00FDch hromad\u011Bn\u00EDm tohoto kovu v organismu a jeho vazbou in vivo mohou sni\u017Eovat tvorbu kysl\u00EDkov\u00FDc"@cs . "http://www.isvav.cz/projectDetail.do?rowId=GA305/00/0365"^^ . "Nov\u00E9 l\u00E1tky chelatuj\u00EDc\u00ED \u017Eelezo - problematika jejich kardiovaskul\u00E1rn\u00EDch, potenci\u00E1ln\u011B kardioprotektivn\u00EDch a biotransforma\u010Dn\u00EDch \u00FA\u010Dink\u016F" .