. "Neuvedeno."@en . "http://www.isvav.cz/projectDetail.do?rowId=GA304/99/0368"^^ . . "Zaveden\u00ED zobrazov\u00E1n\u00ED v re\u00E1ln\u00E9m \u010Dase v odra\u017Een\u00E9m sv\u011Btle konfok\u00E1ln\u00EDho laserov\u00E9ho skanuj\u00EDc\u00EDho mikroskopu otev\u0159elo mo\u017Enost zkoumat okam\u017Eitou vnitrobun\u011B\u010Dnou motilitu u bun\u011Bk in vitro p\u0159i nejvy\u0161\u0161\u00EDm rozli\u0161en\u00ED optick\u00E9ho mikroskopu. Pouze jedin\u00FD v\u00FDrobce NORAN (USA) dod\u00E1v\u00E1 vhodn\u00E9 syst\u00E9my, z nich\u017E prvn\u00ED byl CLSM Odyssey, kter\u00FD umo\u017Enil uk\u00E1zat, \u017Ee uvnit\u0159 bu\u0148ky je v\u0161e v trval\u00E9m pohybu, jen\u017E z\u00E1vis\u00ED na typu bu\u0148ky \u017Eivotnm\u00EDch podm\u00EDnk\u00E1ch anebo chemick\u00E9m p\u016Fsoben\u00ED, a p\u0159inesl rovn\u011B\u017E nov\u00FD pohled na vnitrobun\u011B\u010Dnou dynamickou kompartmentalizaci. Roz\u0161\u00ED\u0159en\u00ED o srovn\u00E1vac\u00ED v\u00FDzkum rychl\u00FDch reakc\u00ED u representativn\u00ED skupiny norm\u00E1ln\u00EDch a n\u00E1dorov\u00FDch bun\u011Bk in vitro je nezbytn\u00E9, aby se tento postup mohl vyu\u017E\u00EDt ke zji\u0161\u0165ov\u00E1n\u00ED okam\u017Eit\u00E9ho stavu bu\u0148ky. Takov\u00E9 vyhodnocen\u00ED p\u0159inese bezprost\u0159edn\u00ED informaci o dopadu experiment\u00E1ln\u00EDch manipulac\u00ED na vnitrobun\u011B\u010Dnou signalizaci, metabolickou stimulaci/inhibici, o dynamick\u00FDch znac\u00EDch malignity, kter\u00E9 jinou metodou nelze zjistit, a o \u010Dasn\u00FDch reakc\u00EDch na expozici toxick\u00E9mu p\u016Fsoben\u00ED. P\u0159i \u00FAsp\u011B" . "2003-04-01+02:00"^^ . "The introduction of video-rate reflection imaging mode in confocal laser scanning microscopy (CLSM) has created the opportunity to investigate motility within cells in vitro at the highest resolution possible with optical microscopy. Only one commercial manufacturer has made a suitable system. This CLSM, the Noran Odyssey, has shown that there is a constant motion inside the cell which reflects the cell type and its living conditions and/or treatment, and has given rise to new insights on dynamic intracellular compartmentalization. An extension of comparative in vitro investigations of a representative set of normal and neoplastic cell types for their fast reactions is needed if this approach is to develop into a useful assessment of actual conditions within the living cell. Such evaluation will bring immediate information about the impact of experimental manipulations on intracellular signalling, metabolic stimulation and/or inhibition, and traits characterizing malignancy and early"@en . "Autor se spolupod\u00EDlel na vytvo\u0159en\u00ED nov\u00E9 metodiky ke studiu \u017Eiv\u00FDch bun\u011Bk. Projekt p\u0159inesl v\u00FDborn\u00E9 v\u00FDsledky , kter\u00E9 v\u0161ak byly velmi chab\u011B publikov\u00E1ny (jeden p\u0159ehledn\u00FD \u010Dl\u00E1nek). Kone\u010Dn\u00E9 hodnocen\u00ED - c\u00EDle projektu byly spln\u011Bny."@cs . . "V\u00FDznam rychl\u00FDch vnitrobun\u011B\u010Dn\u00FDch motilitn\u00EDch reakc\u00ED \u017Eiv\u00FDch bun\u011Bk" . "GA304/99/0368" . . "0"^^ . . . "The significance of fast intracellular motile reactions in living cells"@en . . . . . . "1"^^ . . "3"^^ . . . "0"^^ . "3"^^ . . .