"The Role of Embryonic Stress Proteins in Teratogenesis"@en . "0"^^ . . . . "Jen velmi m\u00E1lo je zn\u00E1mo o odpov\u011Bdi ku\u0159ec\u00EDho z\u00E1rodku na tepeln\u00FD \u0161ok. Hlavn\u00EDm c\u00EDlem projektu je vytvo\u0159it z\u00E1kladn\u00ED \u00FAdaje pro tento experiment\u00E1ln\u00ED model a prov\u00E9st srovn\u00E1n\u00ED abnorm\u00E1ln\u00EDho v\u00FDvoje a stresov\u00E9 odpov\u011Bdi indukovan\u00E9 tepeln\u00FDm \u0161okem s v\u00FDvojov\u00FDmi zm\u011Bnamia stresov\u00FDmi odpov\u011B\u010Fmi vyvolan\u00FDmi chemick\u00FDmi teratogeny. Exprese HSP 70 genu bude sledov\u00E1na na \u00FArovni transkripce i translace. Tk\u00E1\u0148ov\u011B specifick\u00FD obraz indukovan\u00FDch protein\u016F bude sledov\u00E1n s c\u00EDlem objasnit, zda po embryotoxick\u00E9m p\u016Fsoben\u00ED tepla i chemik\u00E1l \u00ED doch\u00E1z\u00ED k akumulaci indukovan\u00FDch protein\u016F ve specifick\u00FDch oblastech ku\u0159ec\u00EDho z\u00E1rodku. Bude testov\u00E1na hypot\u00E9za, zda tk\u00E1\u0148ov\u011B specifick\u00E1 akumulace indukovan\u00FDch protein\u016F souvis\u00ED s abnorm\u00E1ln\u00EDm v\u00FDvojem z\u00E1rodk\u016F." . "GA304/94/1716" . . "6"^^ . "6"^^ . . . . "1"^^ . . . "2"^^ . . "http://www.isvav.cz/projectDetail.do?rowId=GA304/94/1716"^^ . . "\u00DAloha embryon\u00E1ln\u00EDch stresov\u00FDch protein\u016F v teratogenesi" . .