. "Studie potvrdila hypot\u00E9zu projektu: %22V\u00FDvoj norm\u00E1ln\u00ED dentice zahrnuje pu\u010Den\u00ED epitelu a integraci vznikaj\u00EDc\u00EDch pupen\u016F. Zubn\u00ED anom\u00E1lie u tabby my\u0161\u00ED jsou spojeny s\u00A0poruchou r\u016Fstu a integrace jednotliv\u00FDch pupen\u016F.%22 Syntetizovali jsme na\u0161e dosavadn\u00ED n\u00E1lezy o di"@cs . . . "Budding morphogenesis as a mechanism of dentition development"@en . "Neuvedeno."@en . "16"^^ . . . . "16"^^ . "Results of the study have confirmed the project hypothesis: %22Development of normal dentition includes epithelial budding and integration of rising buds. Dental anomalies in mutant mice are associated with a defect in growth and integration of the buds.%22"@en . . . . "The developmental mechanism called %22budding morphogenesis%22 is a process giving rise to epithelial appendages, such as feathers, hair, scales, glands, and teeth, from simple epithelial buds. Contrary to feathers and lungs, this process is not yet well understood in teeth. Aim of the proposed project is to analyze morphological changes of developing teeth, to detect budding regions and to correlate both with data on cell proliferation, adhesion and death in the normal and tabby mice, which exhibit developmental defects of teeth and other ectodermal appendages (hair, glands). The following hypothesis will be verified: A reiterative epithelial budding and integration of originating buds are involved during budding morphogenesis of dentition in normal mice. Dental anomalies in the tabby mice are associated with alterations in growth and integration of the individual buds. Results of the project will contribute to general knowledge on organogenesis by bringing new aspects on the mechanism of"@en . . "Pu\u010Den\u00ED epitelu jako mechanismus v\u00FDvoje dentice" . . . . "GA304/02/0448" . "Pu\u010Den\u00ED epitelu je v\u00FDvojov\u00FD proces, j\u00EDm\u017E z jednoduch\u00FDch pupen\u016F vznikaj\u00ED epitelov\u00E9 deriv\u00E1ty, mezi n\u011B\u017E pat\u0159\u00ED nap\u0159. pe\u0159\u00ED, vlasy, \u0161upiny, \u017El\u00E1zy, pl\u00EDce a zuby. Na rozd\u00EDl od v\u00FDvoje pe\u0159\u00ED a plic, tento proces nen\u00ED dosud dob\u0159e prozkoum\u00E1n p\u0159i v\u00FDvoji zub\u016F. C\u00EDlem navrhovan\u00E9ho projektu je analyzovat morfologick\u00E9 zm\u011Bny vyv\u00EDjej\u00EDc\u00EDch se zubn\u00EDch z\u00E1klad\u016F a detekovat mo\u017En\u00E9 oblasti pu\u010Den\u00ED epitelu. Tyto n\u00E1lezy budeme korelovat s \u00FAdaji o proliferaci, smrti a spojen\u00ED bun\u011Bk v zubn\u00EDch z\u00E1kladech u norm\u00E1ln\u00EDch a tabby mutantn\u00EDchmy\u0161\u00ED, kter\u00E9 maj\u00ED v\u00FDvojov\u00E9 vady zub\u016F a dal\u0161\u00EDch ektodermov\u00FDch deriv\u00E1t\u016F (vlas\u016F, \u017El\u00E1z). Budeme ov\u011B\u0159ovat n\u00E1sleduj\u00EDc\u00ED hypot\u00E9zu: P\u0159i v\u00FDvoji norm\u00E1ln\u00ED my\u0161\u00ED dentice prob\u00EDh\u00E1 opakovan\u00E9 pu\u010Den\u00ED epitelu a doch\u00E1z\u00ED k integraci nov\u011B vznikaj\u00EDc\u00EDch pupen\u016F. Vznik vrozen\u00FDch vad dentice u tabby my\u0161\u00ED je spojen s poruchou r\u016Fstu a integrace jednotliv\u00FDch pupen\u016F. V\u00FDsledky projektu p\u0159inesou nov\u00E9 poznatky o mechanismu v\u00FDvoje zub\u016F, mohou p\u0159isp\u011Bt k obecn\u00FDm znalostem o v\u00FDvoji org\u00E1n\u016F a k\u00A0vysv\u011Btlen\u00ED vzniku n\u011Bkter\u00FDch v\u00FDvojov\u00FDch vad" . "http://www.isvav.cz/projectDetail.do?rowId=GA304/02/0448"^^ . . "1"^^ . . "1"^^ . . "2008-06-02+02:00"^^ . . . . "0"^^ .