"The mechanism of inhibitory action imposed on cyclin-dependenz kinases in malignant human B lymphocytes"@en . "1"^^ . . . "1"^^ . . . . . "The activity of cyclin-dependent kinases and its transport into the nucleus is necessary for the transition through Gl phase and for the progression of S phase. Our primary goal is to study the mechanism of TGFbetal cytostatic effects on the model cell l"@en . "0"^^ . "Projekt se zab\u00FDval anal\u00FDzou a slo\u017Een\u00EDm katalytick\u00FDch komplex\u016F CDK 4 a CDK 6 \u0159\u00EDd\u00EDc\u00EDch bun\u011B\u010Dn\u00FD cyklus. Jedn\u00E1 se o aktu\u00E1ln\u00ED a z\u00E1va\u017Enou problematiku a proto je odborn\u00FD p\u0159\u00EDnos projektu nesporn\u00FD. \u0158e\u0161itel\u00E9 prok\u00E1zali, \u017Ee hlavn\u00ED roli v inhibi\u010Dn\u00EDm p\u016Fsoben\u00ED T"@cs . "http://www.isvav.cz/projectDetail.do?rowId=GA304/01/0564"^^ . "GA304/01/0564" . . "2008-05-30+02:00"^^ . . "Neuvedeno."@en . . . . "Mechanismus inhibice cyklin-dependentn\u00EDch kin\u00E1z u malign\u00EDch B lymfocyt\u016F" . . . . . . "Aktivita cyklin-dependentn\u00EDch kin\u00E1z, podm\u00EDn\u011Bna vazbou katalytick\u00FDch subjednotek, cyklin\u016F, a jejich translokace do j\u00E1dra je nezbytn\u00E1 pro pr\u016Fchod bun\u011Bk El f\u00E1z\u00ED a pro p\u0159echod do S f\u00E1ze. Na bu\u0148k\u00E1ch modelov\u00FDch lini\u00ED odvozen\u00FDch od subtyp\u016F non-Hodgkinsk\u00FDch mali" . "1"^^ . . "0"^^ .