"2008-05-19+02:00"^^ . . . "Neuvedeno."@en . . . . "P\u0159edkl\u00E1dan\u00FD projekt v\u00FDzkumu endometriosy je koncipov\u00E1n jako multidisciplin\u00E1rn\u00ED p\u0159\u00EDstup k \u0159e\u0161en\u00ED problematiky z\u00E1kladn\u00EDho, aplikovan\u00E9ho a klinick\u00E9ho v\u00FDzkumu. Materi\u00E1l odebran\u00FD \u017Een\u00E1m s endo- metriosou bude vyhodnocen: na \u00FArovni sv\u011Bteln\u00E9 a el. mikroskopie bude provedena morfologick\u00E1 anal\u00FDza zam\u011B\u0159en\u00E1 na klasifikaci stupn\u011B diferenciace endometr\u00E1ln\u00EDch komponent s vyj\u00E1d\u0159en\u00EDm kvantit. aspekt\u016F diferenciace bun\u011B\u010Dn\u00FDch organel a zn\u00E1mek degradace endometroidn\u00EDch lo\u017Eisek. Po\u010D\u00EDt\u00E1me s pou\u017Eit\u00EDm metod imunohistochemie pro nalezen\u00ED mo\u017En\u00E9ho markeru. PCR a in situ hybridizace by byla vyu\u017Eita pro jeho identifikaci a mo\u017En\u00FD screeningov\u00FD pr\u016Fkaz autoprotil\u00E1tek. Jejich lokalizace na submikro- mo\u017Enost screeningu plasmatick\u00FDch autoprotil\u00E1tek pova\u017Eujeme za d\u016Fle\u017Eitou jako neinvazivn\u00ED test. Chceme se soust\u0159edit na z\u00EDsk\u00E1n\u00ED pou\u017Eiteln\u00FDch metodick\u00FDch p\u0159\u00EDstup\u016F, kter\u00E9 by bylo mo\u017En\u00E9 pou\u017E\u00EDt ve screeningu. C\u00EDlem bude i snaha na z\u00E1klad\u011B zhodnocen\u00ED v\u00FDsledk\u016F zp\u0159esnit kriteria sou\u010Dasn\u00E9 klasifikace endometriosy.Pl\u00E1novan\u00E1 in situ" . . . "Submitted endometriosis research project is drawn up a multidisciplinary approach to the solution of the problems of basic, applied and clinic research. Material taken from women with endometriosis will be processed and evaluated: morphological analysis focused on the classification of differentiation degree of endometrial components with stating quantitative aspects of cellular organelles differentiation and the signs of degradation of endometriosis foci. We reckon on the usage of immunohistochemistry methods for finding possible marker. PCR and in situ hybridisation would be used for its identification and possible screening assay of auto antibodies. Their localization on submicroscopic level should elucidate the existence of epitops. Even if we can elaborate a large screening, the possibility of plasmatic autoantibodies screening is considered to be important as a non-invasive test. We would like to concentrate on acquiring usable methodic approaches which could be used in screening. Our aim will"@en . "http://www.isvav.cz/projectDetail.do?rowId=GA304/00/1155"^^ . . . "7"^^ . "7"^^ . "Prevalence, diagnostics and therapy of endometriosis"@en . . "GA304/00/1155" . . "1"^^ . . . "1"^^ . . . . . "V morfologick\u00E9 \u010D\u00E1sti studie bylo prok\u00E1z\u00E1no, \u017Ee lo\u017Eiska endometri\u00F3zy nekop\u00EDruj\u00ED v\u011Bt\u0161inou typickou stavbu endometria a \u017Ee centr\u00E1ln\u00ED partie lo\u017Eisek vykazuj\u00ED prim\u00E1rn\u00ED nekr\u00F3zu a po\u010Detn\u00E9 sign\u00E1ly apopt\u00F3zy etc. Byla potvrzena pracovn\u00ED hypot\u00E9za, \u017Ee degradace lo\u017Ei"@cs . "0"^^ . "Pravalence, diagnostika a terapie endometriosy" . .