"Non-invasive testing of the vessel-wall, hyperlipoproteinemia influence on the vessels intima, genetic aspects of hyperlipoproteinemias"@en . "GA303/00/D005" . . "1"^^ . "0"^^ . "Atherosclerosis is a disease of mass incidence. It is a degenerative disturbance of arterial wall, results of which are diseases of cardiovascular system. One of the key-role is played by hyperlipoproteinemias. Thickness of arterial intima is consideredto be the early phase of it. Intima thickness represents today often studied parameter of premature atherosclerosis, therefore. It is well-known, even prior the plaques rise stouts - not at all times homogenously - vascular endothelium, called intima. Intima thickness is routinely evaluated using ultrasonography technique in common carotid artery region. Different hyperlipoproteinemias have contributed to development of atherosclerosis in different arterial localisations. Influence of hypercholesterolemia on vessel wall is considered to be evident. Even hypertriglyceridemias get into the foreground of interest of investigators. In patient suffering with hypertriglyceridemias mainly increasing occurrence of ischemic disease of the lowe"@en . "0"^^ . . . . . . . . . . . "Grant p\u0159ed\u010Dasn\u011B ukon\u010Den z d\u016Fvodu mate\u0159sk\u00E9 dovolen\u00E9 \u0159e\u0161itelky. Z\u00E1v\u011Bre\u010Dn\u00E1 karta projektu je zpracov\u00E1na kompletn\u011B a v souladu s ostatn\u00EDmi zpr\u00E1vami. Vzhledem ke kr\u00E1tk\u00E9mu \u0159e\u0161en\u00ED projektu nejsou \u017E\u00E1dn\u00E9 v\u00FDstupy."@cs . "http://www.isvav.cz/projectDetail.do?rowId=GA303/00/D005"^^ . . "0"^^ . "Ateroskler\u00F3za je onemocn\u011Bn\u00ED hromadn\u00E9ho v\u00FDskytu. Jedn\u00E1 se o degenerativn\u00ED onemocn\u011Bn\u00ED c\u00E9vn\u00ED st\u011Bny, jeho\u017E d\u016Fsledkem jsou onemocn\u011Bn\u00ED kardiovaskul\u00E1rn\u00EDho apar\u00E1tu. Jednou z kl\u00ED\u010Dov\u00FDch \u00FAloh v jej\u00EDm rozvoji hraj\u00ED hyperlipoprotein\u00E9mie (HLP). Za \u010Dasnou f\u00E1zi pova\u017Eujeme roz\u0161\u00ED\u0159en\u00ED intimy velk\u00FDch c\u00E9v. \u0160\u00ED\u0159e intimy je proto dnes velmi studovan\u00FDm parametrem rozvoje p\u0159ed\u010Dasn\u00E9 ateroskler\u00F3zy. Je zn\u00E1mo, \u017Ee je\u0161t\u011B p\u0159ed vznikem pl\u00E1t\u016F se dif\u00FAzn\u011B, ne zcela rovnom\u011Brn\u011B ztlu\u0161\u0165uje c\u00E9vn\u00ED v\u00FDstelka - intima. B\u011B\u017En\u011B se stanovuje \u0161\u00ED\u0159e intimy ultrasonografickou technikou v oblasti arteria carotis communis. Je zn\u00E1mo, \u017Ee jednotliv\u00E9 HLP p\u0159isp\u00EDvaj\u00ED k rozvoji ateroskler\u00F3zy v r\u016Fzn\u00FDch tepenn\u00FDch lokalizac\u00EDch. Vliv hypercholesterol\u00E9mie na st\u011Bnu c\u00E9vn\u00ED je pova\u017Eov\u00E1n za prok\u00E1zan\u00FD. Dnes se v\u0161akdo pop\u0159ed\u00ED z\u00E1jmu dost\u00E1v\u00E1 i hypertriglycerid\u00E9mie. U pacient\u016F s hypertriglycerid\u00E9miemi je zaznamen\u00E1v\u00E1n p\u0159edev\u0161\u00EDm zv\u00FD\u0161en\u00FD v\u00FDskyt ischemick\u00E9 choroby doln\u00EDch kon\u010Detin. C\u00EDlem pr\u00E1ce je zhodnotit vliv jednotliv\u00FDch parametr\u016F lipidov\u00E9ho spektra na intimu velk\u00FDch c" . . . "Nenvazivn\u00ED sledov\u00E1n\u00ED c\u00E9vn\u00ED st\u011Bny, vliv hyperlipoprotein\u00E9mi\u00ED na intimu velk\u00FDch c\u00E9v, genetick\u00E9 aspekty hyperlipoprotein\u00E9mi\u00ED" . . "0"^^ .