. "http://www.isvav.cz/projectDetail.do?rowId=GA301/99/0350"^^ . . . "2003-04-01+02:00"^^ . . "0"^^ . . . . "0"^^ . . . "Screening for and characterization of novel, apoptosis inducing surface molecules of human hematopoietic cells"@en . . "Identifikace a charakterizace nov\u00FDch, apopt\u00F3zu indukuj\u00EDc\u00EDch povrchov\u00FDch molekul lidsk\u00FDch hematopoetick\u00FDch bun\u011Bk" . "1"^^ . "GA301/99/0350" . "Neuvedeno."@en . "\u0158\u00EDzen\u00E1 bun\u011B\u010Dn\u00E1 smrt neboli apopt\u00F3za hraje v\u00FDznamnou roli jak b\u011Bhem embryon\u00E1ln\u00EDho v\u00FDvoje organizmu tak i v cel\u00E9m jeho postnat\u00E1ln\u00EDm \u017Eivot\u011B. Naru\u0161en\u00ED jej\u00ED regulace b\u00FDv\u00E1 jednou z p\u0159\u00ED\u010Din v\u00E1\u017En\u00FDch, \u010Dasto fat\u00E1ln\u00EDch chorob jak\u00FDmi jsou n\u00E1dorov\u00E1 onemocn\u011Bn\u00ED, imunodeficience a neurodegenerativn\u00ED choroby. Sn\u00ED\u017Een\u00E1 citlivost n\u00E1dorov\u00FDch bun\u011Bk k apoptotick\u00FDm sign\u00E1l\u016Fm je zodpov\u011Bdn\u00E1 za jejich vysokou odolnost ke klasick\u00FDm form\u00E1m n\u00E1dorov\u00E9 terapie (radio-\u010Di chemoterapie). Z tohoto d\u016Fvodu se velmi l\u00E1kavou a potenci\u00E1ln\u011Bterapeuticky v\u00FDznamnou apopt\u00F3zu n\u00E1dorov\u00FDch bun\u011Bk, zejm\u00E9na pomoc\u00ED specifick\u00FDch extracelul\u00E1rn\u00EDch sign\u00E1l\u016F. Extracelul\u00E1rn\u00ED proapoptotick\u00E9 sign\u00E1ly b\u00FDvaj\u00ED zprost\u0159edkovan\u00E9 n\u011Bkter\u00FDmi membr\u00E1nov\u00FDmi receptory (nap\u0159. rodiny TNFR). C\u00EDlem p\u0159edkl\u00E1dan\u00E9ho projektu je identifikovat nov\u00E9 apapt\u00F3zu indukuj\u00EDc\u00ED membr\u00E1nov\u00E9 molekuly lidsk\u00FDch hematopetick\u00FDch bun\u011B\u010Dn\u00FDch lini\u00ED a nov\u00E9, apopt\u00F3zu indukuj\u00EDc\u00ED membr\u00E1nov\u00E9 molekuly lidsk\u00FDch hematopoetick\u00FDch bun\u011B\u010Dn\u00FDch lini\u00ED a charakterizovat jimi zprostg\u0159edkovan\u00E9 sign\u00E1ln\u00ED dr\u00E1hy vedouc\u00ED k" . . . "5"^^ . . "5"^^ . . "Bylo testov\u00E1no v\u00EDce ne\u017E 200 monoklon\u00E1ln\u00EDch protil\u00E1tek rozpozn\u00E1vaj\u00EDc\u00EDch povrchov\u00E9 molekuly lidsk\u00FDch hematopoietick\u00FDch bun\u011Bk a bun\u011B\u010Dn\u00FDch lini\u00ED. D\u00E1le byla charaketrizov\u00E1na apoptotick\u00E1 signalizace indukovan\u00E1 immobilizovanou anti-CD53 monoklon\u00E1ln\u00ED protil\u00E1tkou"@cs . . . "Characteristics of the project (an abstract of max. 15 lines): Programmed cell death or apoptosis plays an important role in embryonic development as well as during the postnatal life of an organism. Disruption of its regulation could be one of the causes of such serious human maladies as cancer, various immunodeficiencies and neurodegenerative diseases. The decreased sensitivity of cancer cells to apoptosis-inducing signals is usually responsible for their high resistance to the usual modes of tumor therapy (radio- or chemotherapy). Therefore, the specific induction of apoptosis seems to be a very promising and potentially therapeutically effective way of eradicating cancer cells. One of the options would be to affect extracellular apoptotic signaling that is mainly mediated through certain membrane receptors (e.g. of the TNFR family). Thus, a major goal of this project is the identification of novel apoptosis-inducing membrane molecules on human hematopoetic cell lines and characterization"@en . .