. "2011-12-31+01:00"^^ . "http://www.isvav.cz/projectDetail.do?rowId=GA301/09/0587"^^ . . "FGFR3" . "2015-03-02+01:00"^^ . "2011-04-16+02:00"^^ . "1"^^ . . "Nov\u00E9 dr\u00E1hy FGFR3 signalingu v achondropl\u00E1zii" . . " chrupavka" . "0"^^ . . . "0"^^ . "2009-03-01+01:00"^^ . " inhibitor" . . . "GA301/09/0587" . . . " molekul\u00E1rn\u00ED knihovna" . "Activating mutations in the FGFR3 tyrosine kinase account for several forms of human dwarfism, including achondroplasia, the most common form of human short-limb dwarfism, and a neonatal-lethal thanatophoric dysplasia. Although achondroplasia is considered potentially treatable, there is no cure available at present. This is mostly due to our poor understanding of the mechanism of FGFR3 action in cartilage. Specific inhibition of known FGFR3 signaling pathways in cartilage rescues the FGFR3 effects only partially, strongly suggesting the existence of yet unknown pathways. Our proposal aims on discovery of such pathways through screening of molecular library. Using both chemical and genetic approaches, we will identify and characterize novel pathways of aberrant FGFR3 signaling in cartilage. This should lead to a better understanding of FGFR3 signaling in cartilage so that a treatment for achondroplasia can be found."@en . "8"^^ . . "8"^^ . . . . . "The project was excellent, both in terms of expertise and in terms of disbursement of funds."@en . "FGFR3; inhibitor; molekul\u00E1rn\u00ED knihovna; chrupavka; chondrocyt; kin\u00E1za; achondropl\u00E1zie."@en . "Novel pathways of FGFR3 signaling in achondroplasia"@en . " kin\u00E1za" . "C\u00EDlem projektu je objevit nov\u00E9 sign\u00E1ln\u00ED dr\u00E1hy FGFR3 receptorov\u00E9 tyrozin-kin\u00E1zy v chrupavce metodou skr\u00EDningu molekul\u00E1rn\u00ED knihovny. \u00DA\u010Delem projektu je (A) objasn\u011Bn\u00ED mechanizmu patologick\u00E9ho FGFR3 signalingu v achondropl\u00E1zii a (B) identifikace potenci\u00E1ln\u00EDch mo\u017Enost\u00ED l\u00E9\u010Dby tohoto onemocn\u011Bn\u00ED." . " chondrocyt" . "\u0158e\u0161en\u00ED projektu prob\u011Bhlo v\u00FDte\u010Dn\u011B, jak z hlediska odborn\u00E9ho tak i z hlediska \u010Derp\u00E1n\u00ED finan\u010Dn\u00EDch prost\u0159edk\u016F."@cs . . . . . .