. . . . . "Current epidemiological data suggest that 15% of couples experience infertility and in half this number the problem remains unresolved. The necessary condition for the successful beginning of pregnancy is the embryo implantation. This process is controlled by a hierarchized orchestration of plenty of humoral factors, from which the leukemia inhibitory factor (LIF) and interleukin-11 (IL-11) are regarded to be the key cytokines of the embryo-endometrial crosstalk. Similarly, the row of leukocyte cell types are taking part, which of the NK cells seem to play an important role. Group of infertile women (with special attention to those with repeated failure of infertility treatment) and group of fertile controls will be examined - the LIF and IL-11genes will be screened for mutations and the NK cells populations in the endometrium will be compared. The goal of the study is to contribute to the better understanding of the immunogenetic background of the embryo implantation and that way to increase"@en . . . . . . "2007-05-02+02:00"^^ . . " interleukin-11" . . "embryo implantation" . "2005-01-01+01:00"^^ . . "http://www.isvav.cz/projectDetail.do?rowId=GA301/05/0078"^^ . "\u0158e\u0161itel\u00E9 splnili v\u0161echny c\u00EDle projektu. Byla vy\u0161et\u0159ena skupina 424 infertiln\u00EDch \u017Een - v\u0161echny na mutace v lif genu, polovina z nich na mutace v genu pro IL-11. Kontroln\u00ED skupina pro screening DNA sest\u00E1vala z 202 zdrav\u00FDch plodn\u00FDch \u017Een. V\u00FDsledky prok\u00E1zaly,"@cs . "Detection of mutations in genes coding key embryo-endometrium crosstalk cytokines in idiopathicly infertile women with repeated failure of treatment"@en . "Identifikace mutac\u00ED v genech k\u00F3duj\u00EDc\u00EDch kl\u00ED\u010Dov\u00E9 cytokiny embryo-endometri\u00E1ln\u00ED komunikace u \u017Een s idiopatickou sterilitou a opakovan\u00FDm selh\u00E1n\u00EDm l\u00E9\u010Dby" . " mutation" . "2007-12-31+01:00"^^ . "6"^^ . . "6"^^ . "1"^^ . "Solvers fulfilled all the aims of the project. A group of 424 infertile patients was screened for the lif gene mutations, half of them for the mutations in the gene for IL-11. The control group for the DNA screening comprised of 202 healthy fertile women"@en . . " leukemia-inhibitory factor" . "1"^^ . . . . . . "0"^^ . "2008-12-16+01:00"^^ . "Sou\u010Dasn\u00E9 epidemiologick\u00E9 studie ukazuj\u00ED, \u017Ee 15% p\u00E1r\u016F v reproduk\u010Dn\u00EDm v\u011Bku je neplodn\u00FDch, p\u0159i\u010Dem\u017E u poloviny z nich nen\u00ED l\u00E9\u010Dba \u00FAsp\u011B\u0161n\u00E1. Nutnou podm\u00EDnkou pro \u00FAsp\u011B\u0161n\u00FD za\u010D\u00E1tek t\u011Bhotenstv\u00ED je implantace embrya. Tento proces je kontrolov\u00E1n hierarchizovanou souhrou \u0159ady humor\u00E1ln\u00EDch faktor\u016F, z nich\u017E leukemick\u00FD inhibi\u010Dn\u00ED faktor (LIF) a interleukin-11 (IL-11) jsou pokl\u00E1d\u00E1ny za kl\u00ED\u010Dov\u00E9 cytokiny embryo-endometri\u00E1ln\u00ED komunikace. Implantace se \u00FA\u010Dastn\u00ED t\u00E9\u017E \u0159ada leukocyt\u00E1rn\u00EDch typ\u016F bun\u011Bk, z nich\u017E v\u00FDznamnou roli hraj\u00ED NK bu\u0148ky. U skupiny infertiln\u00EDch \u017Een (se zam\u011B\u0159en\u00EDm na ty, u nich\u017E l\u00E9\u010Dba opakovan\u011B v minulosti selhala) a u fertiln\u00EDch kontrol budou vy\u0161et\u0159eny geny k\u00F3duj\u00EDc\u00ED LIF a IL-11 na v\u00FDskyt mutac\u00ED. Populace NK bun\u011Bk v endometriu fertiln\u00EDch \u017Een a infertiln\u00EDch kontrol budou srovn\u00E1ny. P\u0159edkl\u00E1dan\u00FD projekt p\u0159isp\u011Bje k lep\u0161\u00EDmu pochopen\u00ED imunogenetick\u00E9ho pozad\u00ED implantace embrya a t\u00EDm povede k zv\u00FD\u0161en\u00ED efektivity metod l\u00E9\u010Dby neplodnosti." . "embryo implantation; mutation; leukemia-inhibitory factor; interleukin-11; infertility"@en . "GA301/05/0078" .