"2"^^ . "Apoptosis is a form of programmed cell death that is involved in many important cellular processes. Apoptosis is also observed in cells exposed to stressful stimuli or damage, thereby preventing the maintenance and proliferation of potentially dangerous cells. As the apoptotic system is generally deactivated in growing tumours, a desirable goal of various oncology therapies is to restore responsiveness of cancer cells to apoptotic stimuli. Photodynamic therapy (PDT) is one of the possible treatment modalities using light absorbing molecules (photosensitizers) to generate reactive oxygen species causing cell death. The main objective of this proposal is the development of new and improved photosensitizing agents enabling induction of apoptosis in cancer cells. Our study includes design and synthesis of new macrocyclic compounds exhibiting photosensitizing activity as well as in vitro and in vivo assessment of their action, uptake, localization. PDT efficacy and determination of the mode and"@en . . . . . "11"^^ . . "11"^^ . "Photodymanic therapy (PDT) is one of the treatment modalities using light-absorbing molecules of photosensitizers to generate highly reactive oxygen species causing cell death. Synthesis and functional analysis of a new generation of photosensitizers was"@en . . . "GA301/04/1315" . . "2007-10-16+02:00"^^ . "http://www.isvav.cz/projectDetail.do?rowId=GA301/04/1315"^^ . . "Indukce apopt\u00F3zy macrocyklick\u00FDmi slou\u010Deninami v n\u00E1dorov\u00FDch bu\u0148k\u00E1ch" . . "Induction of apoptosis by macrocyclic compounds in cancer cells"@en . "Fotodynamick\u00E1 terapie (PDT) je jedn\u00EDm z\u00A0mo\u017En\u00FDch l\u00E9\u010Debn\u00FDch postup\u016F, kter\u00FD vyu\u017E\u00EDv\u00E1 sv\u011Btlo absorbuj\u00EDc\u00ED l\u00E1tky, fotosensitiz\u00E9ry, ke tvorb\u011B vysoce reaktivn\u00EDho kysl\u00EDku vyvol\u00E1vaj\u00EDc\u00EDho bun\u011B\u010Dnou smrt. Synt\u00E9za a funk\u010Dn\u00ED anal\u00FDza nov\u00E9 generace fotosensitiz\u00E9r\u016F v\u00A0tomto"@cs . . . . "0"^^ . . . . . . . . . "Apopt\u00F3za je forma programovan\u00E9 bun\u011B\u010Dn\u00E9 smrti, kter\u00E1 hraje d\u016Fle\u017Eitou \u00FAlohu v \u0159ad\u011B bun\u011B\u010Dn\u00FDch proces\u016F. Objevuje se rovn\u011B\u017E v bu\u0148k\u00E1ch vystaven\u00FDch stresov\u00FDm podn\u011Bt\u016Fm nebo po\u0161kozen\u00ED, tak\u017Ee zabra\u0148uje uchov\u00E1v\u00E1n\u00ED a d\u011Blen\u00ED potenci\u00E1ln\u011B nebezpe\u010Dn\u00FDch bun\u011Bk. V rostouc\u00EDch n\u00E1dorech je v\u0161ak apoptick\u00FD syst\u00E9m neaktivn\u00ED, a proto \u017E\u00E1douc\u00EDm c\u00EDlem r\u016Fzn\u00FDch onkologick\u00FDch terapi\u00ED je obnovit odpov\u00EDdavost n\u00E1dorov\u00FDch bun\u011Bk na apoptick\u00E9 podn\u011Bty. Fotodynamick\u00E1 terapie (PDT) je jedn\u00EDm z mo\u017En\u00FDch l\u00E9\u010Debn\u00FDch zp\u016Fsob\u016F, kter\u00FD vyu\u017E\u00EDv\u00E1 sv\u011Btlo absorbuj\u00EDc\u00ED l\u00E1tky (fotosensitiz\u00E9ry) ke tvorb\u011B vysoce reaktivn\u00EDho kysl\u00EDku indukuj\u00EDc\u00EDho bun\u011B\u010Dnou smrt. Hlavn\u00EDm z\u00E1m\u011Brem projektu je vyvinout nov\u00E9 a l\u00E9pe p\u016Fsob\u00EDc\u00ED l\u00E1tky umo\u017E\u0148uj\u00EDc\u00ED indukci apopt\u00F3zy v n\u00E1dorov\u00FDch bu\u0148k\u00E1ch. Na\u0161e studie zahrnuje nejen n\u00E1vrha synt\u00E9zu nov\u00FDch fotoaktivovateln\u00FDch makrocyklick\u00FDch slou\u010Denin, ale i anal\u00FDzu jejich p\u016Fsoben\u00ED jak v in vitro tak in vivo po\u00EDdm\u00EDnk\u00E1ch, d\u00E1le hodnocen\u00ED jejich vstupu do bun\u011Bk, lokalizace, fotodynamick\u00E9 \u00FA\u010Dinnosti a molekul\u00E1rn\u00EDho mechanismu vyvolan\u00E9 bun\u011B\u010Dn\u00E9" . "1"^^ . "Neuvedeno."@en .