"Ned\u00E1vno byl odhalen nov\u00FD, adipocyty sekretovan\u00FD hormon, nazvan\u00FD resistin, jeho\u017E \u00FA\u010Dinky by se mohlo vysv\u011Btlit, jak\u00FDm zp\u016Fsobem podmi\u0148uje obezita inzulinovou rezistenci a diabetes typu 2. V p\u016Fvodn\u00ED publikaci byly u my\u0161\u00EDch model\u016F obezity a inzulinov\u00E9rezistence pops\u00E1ny vysok\u00E9 hladiny cirkuluj\u00EDc\u00EDho resistinu a jejich pokles po pod\u00E1n\u00ED thiazolidinedion\u016F. N\u00E1sledn\u011B publikovan\u00E9 studie ale tyto v\u00FDsledky zpochybnily, kdy\u017E byly v tukov\u00E9 tk\u00E1ni ob\u00E9zn\u00EDch my\u0161\u00ED a potkan\u016F nalezeny sp\u00ED\u0161e sn\u00ED\u017Een\u00E9 hladiny mRNA proresistin. Navzdory t\u011Bmto kontroverzn\u00EDm v\u00FDsledk\u016Fm by mohl objev resistinu pomoci odhalit molekul\u00E1rn\u00ED podstatu koincidence obezity a diabetu typu 2 a mechanismy \u00FA\u010Dink\u016F thiazolidinedion\u016F. V p\u0159edkl\u00E1dan\u00E9m projektu proto navrhujeme analyzovat \u00FA\u010Dinky resistinuu spont\u00E1nn\u011B hypertenzn\u00EDch potkan\u016F kmene SHR, kter\u00FD p\u0159edstavuje u\u017Eite\u010Dn\u00FD zv\u00ED\u0159ec\u00ED model genetick\u00E9 hypertenze, dyslipid\u00E9mie a inzulinov\u00E9 rezistence. Vytvo\u0159\u00EDme transgenn\u00ED SHR linie se zv\u00FD\u0161enou expres\u00ED my\u0161\u00EDho resistinov\u00E9ho transgenu bud' pod kontrolou" . . "2009-01-15+01:00"^^ . "Resistin, nov\u011B objeven\u00FD hormon, sekretovan\u00FD tukovou tk\u00E1n\u00ED, byl navr\u017Een za mo\u017Enou p\u0159\u00ED\u010Dinu asociace obezity s inzulinovou rezistenc\u00ED a diabetem 2. typu. Pro anal\u00FDzu \u00FA\u010Dink\u016F resistinu jsme vytvo\u0159ili novou linii SHR transgenn\u00EDch potkan\u016F, kte\u0159\u00ED exprimuj\u00ED my\u0161\u00ED"@cs . . "Resistin, a hormone secreted by adipose tissue, was proposed to represent a molecular link between obesity, insulin resistance and type 2 diabetes. To analyze the effects of resistin, we derived a new SHR transgenic line that express mouse resistin under"@en . . . "Transgenn\u00ED anal\u00FDza \u00FA\u010Dink\u016F resistinu na metabolismus uhlovod\u00EDk\u016F a tuk\u016F u spont\u00E1nn\u011B hypertenzn\u00EDch potkan\u016F" . "0"^^ . . . "Recently, a new hormone called resistin produced by fat cells was discovered that may provide an explanation for how obesity triggers insulin resistance and type 2 diabetes. In the original report, circulating levels of resistin were high in rodentmodels of obesity and insulin resistance and were reduced by administration of thiazolidinediones. These results were recently questioned by conflicting data on the regulation of resistin expression when the mRNA levels of resistin were shown to berather decreased in adipose tissue of obese rodents. Despite these controversial results, the discovery of resistin has provided a potential molecular link between obesity, type 2 diabetes, and the action of thiazolidinediones. In the currentapplication, we therefore propose to analyze the effects of resistin in the spontaneously hypertensive rat (SHR) which is a well established animal model of genetic hypertension, dyslipidemia, and insulin resistance. Specifically, we will derive"@en . . . . . . . . "Transgenic analysis of the resistin effects on cyrbohydrate and lipid metabolism in spontaneously hypertensive rats"@en . . . "12"^^ . "12"^^ . "http://www.isvav.cz/projectDetail.do?rowId=GA301/03/0751"^^ . "GA301/03/0751" . . "1"^^ . . . . "Neuvedeno."@en . . "1"^^ .