. . "The 11q23 chromosomal rearrangement, involving transcription factor MLL, has been implicated in an variety of acute leukemias (AL). The AL with MLL rearrangement are either de-novo or secondary (therapy related) and are associated with both myeloid and l"@en . . "0"^^ . . "Neuvedeno."@en . . "Hlavn\u00EDmi c\u00EDly projektu bylo 1. Molekul\u00E1rn\u011B genetick\u00E1 a cytogenetick\u00E1 anal\u00FDzy p\u0159estaveb MLL genu u nemocn\u00FDch s akutn\u00ED leukemi\u00ED. Bylo vy\u0161et\u0159eno 21 nemocn\u00FDch 5 z nich m\u011Blo dosud nepopsanou translokaci doprov\u00E1zenou komplexn\u00EDmi p\u0159estavbami chromosom\u016F a jeden,"@cs . . . "1"^^ . . "The study of pathogenesis of acute leukemias (AL) with 11q23 chromosomal rearrangement"@en . "3"^^ . . "0"^^ . . . "3"^^ . "http://www.isvav.cz/projectDetail.do?rowId=GA301/01/0489"^^ . . . . . . . "Studium patogeneze akutn\u00EDch leuk\u00E9mi\u00ED (AL) s p\u0159estavbou chromozomu 11q23" . "GA301/01/0489" . "2008-05-30+02:00"^^ . "Chromosomov\u00E1 zm\u011Bna 11q23 zahrnuj\u00EDc\u00ED p\u0159estavbu genu pro transkrip\u010Dn\u00ED faktor MLL je \u010Dast\u00E1 u r\u016Fzn\u00FDch typ\u016F akutn\u00EDch leuk\u00E9mi\u00ED (AL) se \u0161patnou progn\u00F3zou; jsou to jak de-novo AL tak sekund\u00E1rn\u00ED leuk\u00E9mie, a to jak myeloidn\u00ED tak lymfoidn\u00ED. Z\u00E1m\u011Brem projektu je: A)" .