. . . "http://www.isvav.cz/projectDetail.do?rowId=GA301/00/P089"^^ . "Vliv vitaminov\u00E9 substituce na markery endoteli\u00E1ln\u00ED dysfunkce a koagula\u010Dn\u00ED parametry u osob s prok\u00E1zanou m\u00EDrnou hyperhomocysteinemi\u00ED" . "8"^^ . "GA301/00/P089" . "2008-05-19+02:00"^^ . "Impact of vitamin substitution on endothelial dysfunction markers and coagulation factors in subjects with mild hyperhomocysteinemia"@en . "8"^^ . . "Anotovan\u00E1 studie je pokra\u010Dov\u00E1n\u00EDm v\u00FDzkumn\u00E9ho programu %22Homocystein a vaskul\u00E1rn\u00ED nemoc%22 na n\u011Bm\u017E navrhovatel spolupracoval v letech 1996-98 a kter\u00FD byl podkladem kandid\u00E1tsk\u00E9 diserta\u010Dn\u00ED pr\u00E1ce. C\u00EDlem je prok\u00E1zat v prospektivn\u00ED studii efektivitu vitam\u00EDnov\u00E9 substituce u osob s m\u00EDrnou hyperhomocysteinemi\u00ED na riziko vaskul\u00E1rn\u00ED choroby, endoteli\u00E1ln\u00ED dysfunkci a protrombotickou aktivitu, vyvol\u00E1vanou homocysteinem. Studie bude prov\u00E1d\u011Bna na popula\u010Dn\u00EDch a klinick\u00FDch souborech osob s prok\u00E1zanou m\u00EDrnou hyperhomocysteinemi\u00ED, kter\u00E1 byla definov\u00E1na v r\u00E1mci p\u0159edch\u00E1zej\u00EDc\u00EDch studi\u00ED (MONICA a EuroAspire). Studie je koncipov\u00E1na jako prospektivn\u00ED a otev\u0159en\u00E1. Po 1 m\u011Bs\u00ED\u010Dn\u00ED placebov\u00E9 period\u011B bude n\u00E1sledovat f\u00E1ze s aktivn\u00ED l\u00E9\u010Dbou fol\u00E1ty a d\u00E1le pyridoxinem. Velikostsouboru pot\u0159ebn\u00E9ho k pr\u016Fkazu efektu intervence byla vykalkulov\u00E1na na z\u00E1klad\u011B variability sledovan\u00FDch faktor\u016F v p\u0159edchoz\u00EDch popula\u010Dn\u00EDch studi\u00EDch. V\u011Bdeck\u00E1 hypot\u00E9za vych\u00E1z\u00ED z publikovan\u00FDch \u00FAdaj\u016F o mechanismu p\u016Fsoben\u00ED homocysteinu a byla testovan\u00E1 pilotn\u00ED" . . . . . "The proposed study follows the research programme Homocystem and vascular disease m wtnch tne applicant was involved in the years 1996-98 and which served as a basis for PhD. thesis. The aim of this project is to evaluate in a prospective study the effects of vitamine substitution for risk of vascular disease, endothelial dysfunction and prothrombotic activity in subjects with mild hyperhomocysteinemia. Study population was defined i our previous studies. ( MONICA, EuroAspire) representing population and clinical series. The study is conciept as prospective and open, after one month placebo period an active treatment with folate and pyridoxine will followed. Neccesary sample size for evidence of interevention effect was calculated from ourprevious study, which had estimated the variability of included factors. Scientific hypothesis comes out from published data about patophysiolocal mechanism of homocysteine on the wessel wall and was tested in a pilot study. Outcomes for medical practise"@en . "0"^^ . . . . . . "0"^^ . . "Tento projekt p\u0159inesl 6 jasn\u011B formulovan\u00FDch v\u00FDsledk\u016F ve smyslu prospektivn\u00EDch a epidemiologick\u00FDch studi\u00ED. D\u00E1le obsahuje doporu\u010Den\u00ED pro l\u00E9ka\u0159skou praxi, a to n\u00E1vrh na pod\u00E1v\u00E1n\u00ED fol\u00E1t\u016F u pacient\u016F s m\u00EDrnou hypohomocystein\u00E9mi\u00ED a vysok\u00FDmi koron\u00E1rn\u00EDmi riziky (I"@cs . "1"^^ . . "Neuvedeno."@en . . .