"Projekt navazuje na p\u0159edchoz\u00ED pr\u00E1ci Laborato\u0159e molekul\u00E1rn\u00ED genetiky v oblasti sledov\u00E1n\u00ED minim\u00E1ln\u00ED residu\u00E1ln\u00ED nemoci (MRN) u d\u011Btsk\u00FDch pacient\u016F s akutn\u00ED lymfoblastickou leuk\u00E9mi\u00ED. Jeho c\u00EDlem je doplnit sou\u010Dasn\u00E9 metodiky o nejmodern\u011Bj\u0161\u00ED postupy a jejich pomoc\u00ED vy\u0161et\u0159it ucelen\u00FD soubor nemocn\u00FDch z cel\u00E9 \u010Cesk\u00E9 republiky. V\u00FDsledky studie umo\u017En\u00ED p\u0159isp\u011Bt do diskuse o skute\u010Dn\u00E9m klinick\u00E9m v\u00FDznamu residu\u00E1ln\u00ED nemoci a sou\u010Dasn\u011B se p\u0159ipravit na zaveden\u00ED nov\u00FDch l\u00E9\u010Debn\u00FDch protokol\u016F, kter\u00E9 pou\u017E\u00EDvaj\u00ED vy\u0161et\u0159en\u00ED hladin MRke stratifikaci pacient\u016F do rizikov\u00FDch skupin." . "GA301/00/P055" . . . . . . "2008-05-19+02:00"^^ . . . "http://www.isvav.cz/projectDetail.do?rowId=GA301/00/P055"^^ . "Hlavn\u00EDm c\u00EDlem postdoktorandsk\u00E9ho grantu bylo dopln\u011Bn\u00ED postup\u016F sledov\u00E1n\u00ED MRN u d\u011Btsk\u00FDch ALL o nov\u00E9 modern\u00ED p\u0159\u00EDstupy. V pr\u016Fb\u011Bhu 36 m\u011Bs\u00EDc\u016F \u0159e\u0161en\u00ED \u00FAkolu byla \u0159e\u0161itelem a spolupracovn\u00EDky zavedena a standardizov\u00E1na metoda Realtime Quantitative PCR (RQ-PCR) pro"@cs . "1"^^ . "Neuvedeno."@en . . "3"^^ . "Present proect carry on the previous work of the Laboratory of Molecular Genetics in the field of minimal residual disease (MRD) monitoring in childhood acute lymphoblastic leukaemia. It aims to perfect current techniques with the most recent approaches and examine a well defined cohort of patients from the Czech Republic. The results of this study can contribute to discussion on the real clinical significance of residual disease. Moreover, this project would help in introduction of the new treatment protocols with risk stratification of patients based on MRD levels."@en . . "0"^^ . . . . "Minim\u00E1ln\u00ED residu\u00E1ln\u00ED nemoc - nov\u00E9 metodiky a klinick\u00E1 hodnota" . "3"^^ . . . "0"^^ . . . . "Minimal residual disease - new techniques and clinical value"@en .