"Neuvedeno."@en . . . "2008-05-19+02:00"^^ . . "\u010Cetn\u00E9 studie u lid\u00ED a u zv\u00ED\u0159ec\u00EDch model\u016F nazna\u010Dily, \u017Ee zm\u011Bny v metabolismu mastn\u00FDch kyselin a lipid\u016F mohou p\u0159isp\u011Bt k patogenezi inzulinov\u00E9 rezistence a hypertenze. Bylo prok\u00E1z\u00E1no, \u017Ee (1) kmen spont\u00E1nn\u011B hypertenzn\u00EDch potkan\u016F (SHR) m\u00E1 mutace CD36, kl\u00ED\u010Dov\u00E9hproteinu bun\u011B\u010Dn\u00E9ho transportu mastn\u00FDch kyselin; (2) CD 36 je lokalizov\u00E1n na chromozomu 4 v oblasti, asociovan\u00E9 s poruchami \u00FA\u010Dinku inzulinu a metabolizmu mastn\u00FDch kyselin; (3) p\u0159enosem t\u00E9to oblasti chromozomu 4 z normotenzn\u00EDho kmene BN na pozad\u00ED kmene SHRse obnovila norm\u00E1ln\u00ED exprese CD36 a \u010D\u00E1ste\u010Dn\u011B korigovaly poruchy \u00FA\u010Dinku inzulinu a lipidov\u00E9ho metabolizmu; (4) produkce CD36 transgenn\u00EDch FVB my\u0161\u00ED poskytla rozhoduj\u00EDc\u00ED d\u016Fkaz pro \u00FAlohu CD36 v regulaci \u00FA\u010Dinku inzulinu. Tyto transgenn\u00ED my\u0161\u00ED v\u0161ak nejsou vhodnpro studium vlivu zv\u00FD\u0161en\u00E9 exprese CD36 na regulaci krevn\u00EDho tlaku a asociovan\u00FDch metabolick\u00FDch poruch, proto\u017Ee p\u0159\u00EDjemci CD36 transgenu maj\u00ED norm\u00E1ln\u00ED alely CD36 genu a FVB my\u0161i nejsou spont\u00E1nn\u011B hypertenzn\u00ED. K z\u00EDsk\u00E1n\u00ED defenitivn\u00EDho d\u016Fkazu pro \u00FA\u010Dast genu" . . "0"^^ . . "http://www.isvav.cz/projectDetail.do?rowId=GA301/00/1636"^^ . "0"^^ . "Analysis of the effects of Cd36 (fat) transgene in spontaneously hypertensive rats on clustering of cardiovascular risk factors"@en . . . . "1"^^ . . "Numerous studies in humans and animal models have suggested that alterations in fatty acid and lipid metabolism can contribute to the pathogenesis of insulin resistance and hypertension. It has been demonstrated that: 1) the SHR carriers mutations of CD36, a key protein of the cellular transport of fatty acids; 2)CD36 is located on chromosome 4 at the peak area of linkage to defects in insulin action and fatty acid metabolism; 3) transfer of this region of chromosome 4 from the normotensive BN rat onto SHR background restores normal expression of CD36 and improves cellular defects in insulin sensitivity and lipid metabolism; 4) production of FVB transgenic mice provided a strong evidence for the involvement of CD36 in regulation of insulin action.However, these transgenic mice could not be used to study the effects of CD36 overexpression on regulation of blood pressure (BP) because the FVB mice carry a wild type allele of CD36 gene and are not spontaneously hypertensive. To obtain a definitive"@en . . . "6"^^ . . . . "6"^^ . . . . "Anal\u00FDza \u00FA\u010Dinku Cd36 (Fat) transgenu u spont\u00E1nn\u011B hypertenzn\u00EDch potkan\u016F na koincidenci rizikov\u00FDch faktor\u016F kardiovaskul\u00E1rn\u00EDch onemocn\u011Bn\u00ED" . "CD36 gen k\u00F3duje kl\u00ED\u010Dov\u00FD protein bun\u011B\u010Dn\u00E9ho transportu mastn\u00FDch kyselin. Poruchy metabolizmu mastn\u00FDch kyselin jsou pova\u017Eov\u00E1ny za mo\u017En\u00E9 determinanty inzulinov\u00E9 rezistence. Komplementa\u010Dn\u00ED anal\u00FDza, uskute\u010Dn\u011Bn\u00E1 pomoc\u00ED nov\u00FDch SHR transgenn\u00EDch lini\u00ED s norm\u00E1ln\u00EDm"@cs . . "GA301/00/1636" .