. . "1"^^ . "Genetick\u00E1 a molekul\u00E1rn\u00ED anal\u00FDza variabiln\u00EDho imprintov\u00E1n\u00ED sav\u010D\u00EDho genomu" . . "1"^^ . "0"^^ . . . . . "Genetic Amd Molecular Analysis of Variations in Parental Imprinting of Mammalian Genome."@en . . "Pro v\u0161echny dosud zn\u00E1m\u00E9 imprintovan\u00E9 geny je charakteristick\u00E1 monoaletick\u00E1 exprese p\u016Fsoben\u00E1 z\u00E1stavou transkripce ze suprimov\u00E9 alely.Z p\u0159edchoz\u00EDch v\u00FDsledk\u016F (Forejt a Gregorov\u00E1, 1972 a nepublikovan\u00E9 v\u00FDsledky) jsme z\u00EDskali data indukuj\u00EDc\u00ED existenci nov\u00E9ho genetick\u00E9ho mechanismu:ne\u00FApln\u00E9 (variabiln\u00ED) imprintov\u00E1n\u00ED my\u0161\u00EDch gen\u016F Tme (T-associated maternal effect) a T (Brachyury).Alternativn\u00ED interpretace z\u00EDskan\u00FDch n\u00E1lez\u016F, alespo\u0148 pro gen T by p\u0159edpokl\u00E1dala, \u017Ee gen T s\u00E1m nen\u00ED imprintovan\u00FD, ale jeho exprese je reglov\u00E1na zat\u00EDm nezn\u00E1m\u00FDm imprintovan\u00FDm genem.Navrhovan\u00FD projekt m\u00E1 za c\u00EDl rozli\u0161it mezi ob\u011Bmi alternativami a potvrdit nebo vyvr\u00E1tit existenci ne\u00FApln\u00E9ho imprintov\u00E1n\u00ED.D\u00E1le bude studov\u00E1na evolu\u010Dn\u00ED konzervace imprintov\u00E1n\u00ED gen\u016F Igf 2 a Igf2r mezi my\u0161\u00ED apotkanemO\u010Dek\u00E1van\u00E9 v\u00FDsledky by m\u011Bly p\u0159in\u00E9st nov\u00E9 argumenty do hled\u00E1n\u00ED funkce genomick\u00E9ho imprintov\u00E1n\u00ED.Pokud bude potvrzena hypot\u00E9za o existenci variabiln\u00EDho imprintov\u00E1n\u00ED, pak by tento specifick\u00FD regula\u010Dn\u00ED mechanismus mohl poskytnout vysv\u011Btlen\u00ED tak\u00E9 pro modifikaci" . "http://www.isvav.cz/projectDetail.do?rowId=GA206/94/1478"^^ . . . . "GA206/94/1478" . "1"^^ . . "1"^^ . .