. "2012-12-31+01:00"^^ . " axolotl" . . " evolution" . . . "http://www.isvav.cz/projectDetail.do?rowId=GA206/09/1007"^^ . . "2009-01-01+01:00"^^ . . . . "Germ-layer origin of teeth in the oro-pharyngeal cavity: revising the homology and evolution of vertebrate teeth"@en . "2012-03-30+02:00"^^ . "teeth" . "The project brought evidence that tooth development is controlled by identical molecular signals regardless of their development in the ectoderm or endoderm. Such teeth are homologous structures irrespective of different embryonic origin. Four papers were published in journals with good impact factor. International response illustrated chapter in a book published by Cambridge University Press."@en . . "2014-01-30+01:00"^^ . . "Z\u00E1rode\u010Dn\u00E9 vrstvy, vznik zub\u016F a v\u00FDvojov\u00E1 dynamika orofaci\u00E1ln\u00ED oblasti obratlovc\u016F" . " ontogenesis" . . . . "0"^^ . . . " homology" . "0"^^ . . "1"^^ . "Teeth are one of the vertebrate key innovations, but their evolutionary origins are still a matter of debate. It is believed that teeth evolved either "outside-in" from skin (ectodermal), or "inside-out" from internal (endodermal) denticles. The dilemma, however, cannot be decided based on fossils and the embryogenetic studies did not provide a satisfactory answer as well. Our previous study demonstrated quite convincingly that oral teeth can be derived from either ecto- or endoderm, and even from both sources, and that all such teeth look otherwise identical. In the proposed project, we will analyze the gene expressions appearing during morphogenesis of these teeth, will compare the patterns of teeth development in axolotl and bichir in order to\u00A0 test a hypothesis that all teeth are produced by identical developmental-genetic mechanisms. Our study will address a question whether the developmental module producing teeth evolved only once and teeth of different clades are homologous."@en . . "Zuby pat\u0159\u00ED k z\u00E1sadn\u00EDm obratlov\u010D\u00EDm inovac\u00EDm, nicm\u00E9n\u011B jejich evolu\u010Dn\u00ED historie je st\u00E1le pln\u00E1 otazn\u00EDk\u016F. Dle klasick\u00FDch teori\u00ED zuby vznikly z povrchov\u00FDch (ektoderm\u00E1ln\u00EDch) dentikul (tedy tzv. "outside-in"), nov\u00E9 hypot\u00E9zy mluv\u00ED naopak o vzniku z vnit\u0159n\u00EDch (endoderm\u00E1ln\u00EDch) struktur ("inside-out"). Rozhodnout toto dilema na z\u00E1klad\u011B fosiln\u00EDho z\u00E1znamu nelze, dosavadn\u00ED embryologick\u00E9 studie tohoto c\u00EDle rovn\u011B\u017E nedos\u00E1hly. Na\u0161e p\u0159edchoz\u00ED studie v\u0161ak p\u0159edv\u011Bd\u010Div\u011B demonstrovala, \u017Ee or\u00E1ln\u00ED zuby mohou b\u00FDt odvozeny jak z ekto-, tak i z entodermu a mohou dokonce vznikat z obou vrstev sou\u010Dasn\u011B; p\u0159esto v\u0161ak takov\u00E9 zuby vypadaj\u00ED identicky.V navrhovan\u00E9m projektu chceme pomoc\u00ED genov\u00E9 exprese zjistit, zda-li v\u0161echny zuby (na p\u0159\u00EDkladu axolotla a bichira) jsou produkov\u00E1ny identick\u00FDmi v\u00FDvojov\u011B-genetick\u00FDmi mechanismy, tedy zda regula\u010Dn\u00ED moduly zubn\u00ED morfogenese vznikly pouze jednou a tradi\u010Dn\u00ED p\u0159edpoklad homologie obratlov\u010D\u00EDch zub\u016F st\u00E1le plat\u00ED." . . "Projekt p\u0159inesl poznatky, kter\u00E9 uk\u00E1zaly, \u017Ee v\u00FDvoj zubu \u0159\u00EDd\u00ED identick\u00E9 molekul\u00E1rn\u00ED sign\u00E1ly bez ohledu na jejich v\u00FDvoj v ektodermu nebo v entodermu. Takov\u00E9 zuby jsou homologn\u00ED struktury bez ohledu na odli\u0161n\u00FD embryon\u00E1ln\u00ED p\u016Fvod. \u010Cty\u0159i pr\u00E1ce byly publikov\u00E1ny v \u010Dasopisech s dobr\u00FDm impakt faktorem. Mezin\u00E1rodn\u00ED ohlas dokl\u00E1d\u00E1 kapitola v monografii vydan\u00E9 v Cambridge University Press."@cs . "GA206/09/1007" . "teeth; ontogenesis; evolution; homology; axolotl; bichir"@en . "6"^^ . . "6"^^ .