"Neur\u00E1ln\u00ED, bun\u011B\u010Dn\u00E1 a molekul\u00E1rn\u00ED podstata magnetick\u00E9ho smyslu" . "magnetic compass sense" . . . . "Mnoz\u00ED \u017Eivo\u010Dichov\u00E9 dok\u00E1\u017E\u00ED vn\u00EDmat magnetick\u00E9 pole Zem\u011B, fyziologick\u00FDm mechanizm\u016Fm t\u00E9to schopnosti v\u0161ak rozum\u00EDme jen m\u00E1lo. Navrhovan\u00FD projekt, kombinuj\u00EDc\u00ED behavior\u00E1ln\u00ED, neurobiologick\u00E9 a genetick\u00E9 p\u0159\u00EDstupy, je zam\u011B\u0159en na studium neur\u00E1ln\u00ED, bun\u011B\u010Dn\u00E9 a molekul\u00E1rn\u00ED podstaty magnetick\u00E9 orientace u modelov\u00FDch druh\u016F. Budou provedeny n\u00E1sleduj\u00EDc\u00ED experimenty: 1)\u00A0V\u00A0s\u00E9rii deaferenta\u010Dn\u00EDch experiment\u016F budeme testovat roli trigemin\u00E1ln\u00EDho a zrakov\u00E9ho syst\u00E9mu v\u00A0magnetick\u00E9 orientaci rypo\u0161\u016F druhu Cryptomys anselli. Testov\u00E1n bude vliv lok\u00E1ln\u00ED anest\u00E9zie, oboustrann\u00E9ho p\u0159et\u011Bt\u00ED nervus ophthalmicus a enukleace. U t\u00E9ho\u017E druhu budeme s\u00A0pou\u017Eit\u00EDm n\u011Bkolika technik p\u00E1trat po biogenn\u00EDm magnetitu. 2) S\u00A0pou\u017Eit\u00EDm dvoufotonov\u011B excitovan\u00E9ho fluorescen\u010Dn\u00EDho m\u011B\u0159en\u00ED zm\u011Bn vnitrobun\u011B\u010Dn\u00FDch koncentrac\u00ED v\u00E1pn\u00EDku vyvolan\u00FDch modelovou magnetickou a sv\u011Btelnou stimulac\u00ED budeme hledat magnetoreceptory v\u00A0s\u00EDtnici \u010Dervenky obecn\u00E9 Erithacus rubecula a v pine\u00E1ln\u00EDm komplexu u dr\u00E1patky obecn\u00E9 Xenopus laevis. 3) S\u00A0pou\u017Eit\u00EDm techniky RNA" . . . "2009-10-22+02:00"^^ . "2008-04-25+02:00"^^ . "0"^^ . "2"^^ . "2"^^ . "1"^^ . "2006-01-01+01:00"^^ . . "0"^^ . "S pou\u017Eit\u00EDm r\u016Fzn\u00FDch p\u0159\u00EDstup\u016F a technik jsme studovali neur\u00E1ln\u00ED, bun\u011B\u010Dnou a molekul\u00E1rn\u00ED podstatu magnetick\u00E9 kompasov\u00E9 orientace u t\u0159\u00ED modelov\u00FDch druh\u016F: rypo\u0161e Ansellova (Fukomys anselli), po\u0161tovn\u00EDho holuba (Columba livia) a \u010Dervenky obecn\u00E9 (Erithacus rubec"@cs . . . "Using a variety of approaches and techniques, we have studied the neural, cellular and molecular basis of magnetic compass orientation in three model species: Ansell's mole-rat (Fukomys anselli) and homing pigeon (Columba livia) and the European robin (E"@en . . " magnetoreception" . . . "http://www.isvav.cz/projectDetail.do?rowId=GA206/06/1469"^^ . . "2008-12-31+01:00"^^ . "GA206/06/1469" . . . "The neural, cellular and molecular basis of the magnetic compass sense"@en . "Diverse animals can sense the Earth's magnetic field, but little is known about the physiological mechanisms that underlie this sensory ability. Combining behavioural, neurobiological and genetic approaches, the proposed project addresses the neural, cellular and molecular basis of the magnetic compass orientation in several model species. 1) In a series of deaferentation experiments we will examine the involvement of the trigeminal and the visual systems in the compass orientation of the Ansell's mole rat Cryptomys anselli. The deaferentation paradigms will include local anaesthesia, bilateral transsection of the ophthalmic nerve and enucleation. Using a number of methods we will also search for the biogenic magnetite in this species. 2) Using two photon imaging of intracellular calcium concentration changes induced by model magnetic and light stimulation we will look for magnetoreceptors in the retina of the European robin Erithacus rubecula and within the pineal complex of Xenopus laevis. 3)"@en . . . . . . "magnetic compass sense; magnetoreception; sensory biology"@en .