"Leishmania; Phlebotomus; epidemiology; transmission; bloodsucking vectors"@en . "Prov\u00E1d\u011Bli jsme v\u00FDzkum v ohnisku lidsk\u00E9 ko\u017En\u00ED leishmani\u00F3zy v Turecku. Jako p\u016Fvodce byla identifikov\u00E1na L. infantum, v\u011Bt\u0161inou zp\u016Fsobuj\u00EDc\u00ED viscer\u00E1ln\u00ED leishmani\u00F3zu. Vektorem je Phlebotomus tobbi, z n\u011Bho\u017E jsme celkem z\u00EDskali 11 isol\u00E1t\u016F. Porovn\u00E1n\u00ED s kmeny, kte"@cs . . . "Prvoci rodu Leishmania jsou p\u016Fvodci r\u016Fzn\u00FDch lidsk\u00FDch onemocn\u011Bn\u00ED, a jsou zodpov\u011Bdn\u00ED za morbiditu a mortalitu v tropick\u00FDch a subtropick\u00FDch oblastech sv\u011Bta. V sou\u010Dasnosti se objevuj\u00ED nov\u00E1 ohniska onemocn\u011Bn\u00ED, kde nen\u00ED dostate\u010Dn\u011B \u010Di v\u016Fbec zn\u00E1ma epidemiologie,p\u0159ena\u0161e\u010Di, ani potenci\u00E1ln\u00ED rezervo\u00E1rov\u00ED hostitel\u00E9. Pl\u00E1nujeme studovat cyklus a p\u0159ena\u0161e\u010De ko\u017En\u00ED leishmani\u00F3zy v ohnisku v jihov\u00FDchodn\u00EDm Turecku. Ur\u010Den\u00ED druhu parazita, p\u0159ena\u0161e\u010De a mo\u017En\u00FDch rezervo\u00E1r\u016F p\u0159isp\u011Bje nejen k pozn\u00E1n\u00ED biologie leishmani\u00ED, ale tak\u00E9 pom\u016F\u017Ee zamezit p\u0159enosu na \u010Dlov\u011Bka. P\u0159edpokl\u00E1d\u00E1me vytvo\u0159en\u00ED nov\u00E9ho laboratorn\u00EDho modelu p\u0159enosu parazita zalo\u017Een\u00EDm nov\u00E9 kolonie flebotoma a ur\u010Den\u00EDm nejvhodn\u011Bj\u0161\u00EDho laboratorn\u00EDho hostitele. Molekul\u00E1rn\u00ED faktory ovliv\u0148uj\u00EDc\u00ED interakci vektor-parazit budou studov\u00E1ny se z\u0159etelem na roli st\u0159evn\u00EDch glykoprotein\u016F ve vektorov\u00E9 kapacit\u011B flebotom\u016F. Krom\u011B toho chceme prov\u011B\u0159it existenci kryptick\u00FDch druh\u016F potenci\u00E1ln\u00EDch vektor\u016F." . " transmission" . "Leishmania" . "Human cutaneous leishmaniasis was studied in a focus in Turkey. L. Infantum was identified as a causing agent, the vector was Phlebotomus (Paraphlebotomus) tobbi. Eleven isolates were obtained from sand flies, and were identical with human isolates. P. t"@en . . " epidemiology" . . " Phlebotomus" . "0"^^ . . "0"^^ . "http://www.isvav.cz/projectDetail.do?rowId=GA206/05/0370"^^ . "4"^^ . "4"^^ . "1"^^ . . "GA206/05/0370" . "2005-01-01+01:00"^^ . . . . . . . . . "2007-12-31+01:00"^^ . . "Transmission and vectors of cutaneous leishmaniasis"@en . "Leishmania parasites are the causing agents of a variety of human diseases, and are responsible for morbiditity and mortality in tropical and subtropical regions. New foci are recently emerging, in which the epidemiology, vectors, and potential reservoirhosts are poorly known or unknown. We plan to study transmission cycle and vectors of cutaneous leishmaniasis in a focus in SE Turkey. Parasite identification, incrimination of vectors and potential reservoir hosts will not only contribute to the knowledge of the biology of Leishmania, but also will help to control the disease transmission. Specifically, we suppose that we will develop a new model for study of parasite transmission by establishing a colony of the sand fly vector and determining the most suitable mammalian laboratory host. Molecular factors affecting vector-parasite interaction will be studied focusing on the role of midgut glycoproteins in vectorial capacity of sand flies, as well as potential existence of sibling species of"@en . "P\u0159enos a vekto\u0159i ko\u017En\u00ED leishmani\u00F3zy" . . "2008-12-16+01:00"^^ . "2007-05-02+02:00"^^ . . . .