. "Komunikace mezi bu\u0148kami hraje z\u00E1sadn\u00ED roli p\u0159i v\u00FDvoji vy\u0161\u0161\u00EDch eukaryotick\u00FDch organizm\u016F a poruchy v t\u00E9to komunikaci mohou m\u00EDt za n\u00E1sledek nekontrolovanou bun\u011B\u010Dnou proliferaci a onkogenn\u00ED r\u016Fst. Jednobun\u011B\u010Dn\u00E9 organizmy, kvasinky, rostouc\u00ED na pevn\u00E9m agarov\u00E9m m\u00E9diu, vytv\u00E1\u0159ej\u00ED organizovan\u00E9 struktury, kolonie, kter\u00E9 maj\u00ED morfologicky specifickou pro dan\u00FD kvasinkov\u00FD druh, a v nich\u017E se individu\u00E1ln\u00ED bu\u0148ky chovaj\u00EDi koordinovan\u011B. V p\u0159edchoz\u00EDch experimentech jsme zjistili, \u017Ee krom\u011B p\u0159edpokl\u00E1dan\u00FDch sign\u00E1l\u016F na kr\u00E1tkou vzd\u00E1lenost mezi bu\u0148kami uvnit\u0159 kolonie, existuje signalizace na dlouhou vzd\u00E1lenost mezi jednotliv\u00FDmi koloniemi. Jako substanci zprost\u0159edkov\u00E1vaj\u00EDc\u00ED signalizaci mezi koloniemi jsme identifikovali plynnou l\u00E1tku, amoniak, kter\u00FD je produkov\u00E1n kvasinkov\u00FDmi koloniemi v pulsech (Palkova et al, Nature 390: 532-536, 1997). C\u00EDlem p\u0159edkl\u00E1dan\u00E9ho projektu je studovat molekul\u00E1rn\u00ED mechanizmy sign\u00E1ln\u00EDch syst\u00E9m\u016F uvnit\u0159 i mezi koloniemi pomoc\u00ED 1) anal\u00FDzy mutovan\u00FDch kmen\u016F Sacharomyces cerevisiae s poruchami signalizace" . "0"^^ . . "http://www.isvav.cz/projectDetail.do?rowId=GA204/99/1196"^^ . . . . . "The cell - cell communication plays a crucical role in the development of higher eucaryotic organisms and its defects lead often to uncontrolled cell proliferation and oncogenic growth. Unicellular organisms, yeasts, growing on solid agar medium, are able to create a highly organised structure - colony with morphology specific for different yeast species, where individual cells act in a cooperative manner. In our previous experiments we found that beside assumed short range signals between cells inside the colony, long-distance signalling between individual yeast colonies exists. We identified volatile alkaline compound - ammonia - transmitted by yeast colonies in pulses as a substance mediating the intercolony signal (Palkova et al, Nature 390:532-536, 1997). Aims of the proposed project are to study molecular mechanisms of inter- and intra-colony signalling systems by 1) analysis of mutated strains of Saccharomyces cerevisiae with defects in colony signalling and morphology 2) isolation of ge"@en . . "Yeast colonies: morphology and signalling"@en . . "14"^^ . "Neuvedeno."@en . "14"^^ . "GA204/99/1196" . "Jedn\u00E1 se o projekt vysok\u00E9 odborn\u00E9 kvality, kter\u00FD p\u0159in\u00E1\u0161\u00ED zcela nov\u00E9 a z\u00E1sadn\u00ED informace o dosud nestudovan\u00E9m jevu s pou\u017Eit\u00EDm nejmodern\u011Bj\u0161\u00EDch metod molekul\u00E1rn\u00ED biologie a genetiky (technika mikro\u010Dip\u016F - DNA microarrays). V\u00FDsledky uveden\u00E9 v z\u00E1v\u011Bre\u010Dn\u00E9 kart\u011B"@cs . . "2003-04-01+02:00"^^ . . . . . . "1"^^ . . "Kvasinkov\u00E9 kolonie: Morfologie a sign\u00E1ln\u00ED syst\u00E9my" . . "0"^^ . .