"Pax6 gene is an especially interesting example of the gene controlling developmental program of the organ (eye) in organisms as divergent as human and Drosophila. Mutations in Drosophila Pax6/eyless gene as well as in the mouse or the human Pax6 genes lead to defects in eye development (Small eye in the mouse, aniridia in humans), whereas misexpression of the Drosophila or murine Pax6 results in the formation of additional eyes. Three genes, sine oculis, eyes absent, and dachshund have been proposed tact downstream of Pax6/eyless in Drosophila. In addition, a complex set of protein-protein interactions has been found to take place among protein products encoded by these genes. We want to study molecular mechanisms operating within the vertebrate (human and mouse) Pax6 pathway. In particular, we will focus on the crosstalk between the genes in the pathway that exists at the level of transcriptional regulation and protein-protein interaction."@en . "2003-04-01+02:00"^^ . "5"^^ . "Gen Pax6 je zaj\u00EDmav\u00FDm p\u0159\u00EDkladem genu \u0159\u00EDd\u00EDc\u00EDho v\u00FDvojov\u00FD program org\u00E1nu (v tomto p\u0159\u00EDpad\u011B oka) u organism\u016F tak evolu\u010Dn\u011B vzd\u00E1len\u00FDch jako je \u010Dlov\u011Bk a drosofila. Mutace v genu Pax6/eyeless u drosofily zp\u016Fsob\u00ED stejn\u011B jako mutace v my\u0161\u00EDm nebo lidsk\u00E9m Pax6 genu po\u0161kozen\u00ED oka b\u011Bhem jeho embryon\u00E1ln\u00EDho v\u00FDvoje (mutantn\u00ED my\u0161 Small eye, aniridia u \u010Dlov\u011Bka). C\u00EDlen\u00E1 exprese genu Pax6/eyless v jin\u00FDch oblastech embrya vede k tvorb\u011B dal\u0161\u00EDch (ektopick\u00FDch) o\u010D\u00ED. T\u0159i geny, a to sine oculis, eyes absent a dachshund, byly geneticky um\u00EDst\u011Bny v dr\u00E1ze genu Pax6/eyless pod tento gen. Z\u00E1rove\u0148 byly objeveny protein-proteinov\u00E9 interakce mezi produkty t\u011Bchto gen\u016F. N\u00E1\u0161 projekt je zam\u011B\u0159en na studium dr\u00E1hy genu Pax6 u obratlovc\u016F (zejm\u00E9na u my\u0161i a \u010Dlov\u011Bka). Cht\u011Bli bychom se zam\u011B\u0159it nanal\u00FDzu vz\u00E1jemn\u00FDch vazeb mezi geny na \u00FArovni transkrip\u010Dn\u00ED regulace a protein-proteinov\u00FDch interakc\u00ED." . . . "5"^^ . . . . "0"^^ . . . "1"^^ . "http://www.isvav.cz/projectDetail.do?rowId=GA204/99/0105"^^ . . . . . "Molecular mechanism within the Pax6 pathway controlling eye development"@en . "Projekt v\u00FDznamn\u00FDm zp\u016Fsobem p\u0159isp\u011Bl k detailn\u011Bj\u0161\u00EDmu pozn\u00E1n\u00ED molekul\u00E1rn\u00EDch mechanizm\u016F regula\u010Dn\u00ED dr\u00E1hy zprost\u0159edkov\u00E1van\u00E9 rodinou protein\u016F Pax (zejm\u00E9na Pax 6 a 4). Poda\u0159ilo se prok\u00E1zat rozd\u00EDly v P vlastnostech t\u011Bchto 2 bl\u00EDzce p\u0159\u00EDbuzn\u00FDch protein\u016F. Byly vytypo"@cs . "0"^^ . . . "GA204/99/0105" . . "Studium molekul\u00E1rn\u00EDch mechanism\u016F v dr\u00E1ze Pax6 genu \u0159\u00EDd\u00EDc\u00ED v\u00FDvoj oka" . . "Neuvedeno."@en .