. . . . "Studium biologicky z\u00E1va\u017En\u00FDch po\u0161kozen\u00ED odpov\u011Bdn\u00FDch za kancerogenezi indukovanou z\u00E1\u0159en\u00EDm" . "13"^^ . "http://www.isvav.cz/projectDetail.do?rowId=GA204/93/2451"^^ . "13"^^ . . . . "Identification of Biologically Significant Lesions Responsible for Radiation-Induced Carcinogenesis"@en . "0"^^ . . . "Projekt p\u0159edstavuje kompaktn\u00ED studii genetick\u00FDch \u00FA\u010Dink\u016F ionizuj\u00EDc\u00EDho z\u00E1\u0159en\u00ED na bun\u011B\u010Dn\u00E9 a molekul\u00E1rn\u00ED \u00FArovni. Poskytne z\u00E1kladn\u00ED informace o povaze a vlastnostech radia\u010Dn\u011B indukovan\u00FDch po\u0161kozen\u00ED odpov\u011Bdn\u00FDch za biologick\u00E9 \u00FA\u010Dinky z\u00E1\u0159en\u00ED (reproduk\u010Dn\u00ED smrt bu\u0148ky, mutageneze, neoplatick\u00E1 transformace). Pou\u017Eit\u00E9 p\u0159\u00EDstupy. a) detekce po\u0161kozen\u00ED indukovan\u00FDch z\u00E1\u0159en\u00EDm; b) stanoven\u00ED biologick\u00FDch reakc\u00ED bun\u011Bk na oz\u00E1\u0159en\u00ED; c) modelov\u00E1n\u00ED indukce po\u0161kozen\u00ED pomoc\u00ED Monte Carlo simulace struktury stopy nabit\u00E9 \u010D\u00E1stice. Z\u00E1vislot uveden\u00FDch efekt\u016F na typ\u016F z\u00E1\u0159en\u00ED a podm\u00EDnk\u00E1ch oza\u0159ov\u00E1n\u00ED umo\u017En\u00ED z\u00EDskat \u00FAdaje nezbytn\u00E9 pro pro identifikaci biologicky z\u00E1va\u017En\u00FDch po\u0161kozen\u00ED DNA. XXX" . "1"^^ . . "1"^^ . . . . . "XXX"@cs . "GA204/93/2451" .