. . . "CpG methylation of proviral DNA is the key mechanism of transcriptional regulation of retroviruses by the host cell. We and others have obtained preliminary data that the sequence-specific pattern of methylation, i.e. the methylation status of discrete C"@en . . "Vzorec methylace DNA regula\u010Dn\u00EDch sekvenc\u00ED retrovir\u016F" . "Methylace cytosinu v DNA provir\u016F je kl\u00ED\u010Dov\u00FD mechanismus transkrip\u010Dn\u00ED regulace retrovir\u016F hostitelskou bu\u0148kou. P\u0159edb\u011B\u017En\u00E9 v\u00FDsledky z na\u0161\u00ED i z jin\u00FDch laborato\u0159\u00ED indikuj\u00ED, \u017Ee sekven\u010Dn\u011B specifick\u00FD vzorec methylace, tj. methyla\u010Dn\u00ED stav konkr\u00E9tn\u00EDch dinukleotid\u016F" . "8"^^ . "Projekt se zab\u00FDval problematikou methylace DNA regula\u010Dn\u00EDch sekvenc\u00ED retrovir\u016F. Auto\u0159i prok\u00E1zali, \u017Ee integrace proviru do methylovan\u00E9ho m\u00EDsta hostitelsk\u00E9ho geonomu vede k hypometylaci. Byly prok\u00E1z\u00E1ny rozd\u00EDly v methylaci u sav\u010D\u00EDch a pta\u010D\u00EDch bun\u011Bk, pravd\u011Bpo"@cs . "8"^^ . . . . "1"^^ . . "GA204/01/0632" . . . . . . "0"^^ . "2008-05-30+02:00"^^ . "Neuvedeno."@en . . "Pattern of DNA methylation in retroviral regulatory sequences"@en . . "0"^^ . . "http://www.isvav.cz/projectDetail.do?rowId=GA204/01/0632"^^ . .