"Odborn\u00FD p\u0159\u00EDnos projektu spo\u010D\u00EDv\u00E1 v z\u00EDsk\u00E1n\u00ED nov\u00FDch poznatk\u016F v orientovan\u00E9 imobilizaci enzym\u016F a protil\u00E1tek na modifikovan\u00FDch celulozov\u00FDch nosi\u010D\u00EDch a jejich vyu\u017Eit\u00ED v praxi. Na projektu pracovalo \u0161est student\u016F a jeden doktorand. V\u00FDsledky jsou v\u00FDsti\u017En\u011B pops\u00E1n"@cs . "http://www.isvav.cz/projectDetail.do?rowId=GA203/98/1231"^^ . . "Projekt je zam\u011B\u0159enna vyu\u017Eit\u00ED biosf\u00E9rick\u00FDch interakc\u00ED pro izolace a orientovanou imobilizaci protein\u016F. Je pokra\u010Dov\u00E1n\u00EDm ji\u017E p\u011Btadvacetilet\u00E9ho \u010Desk\u00E9ho v\u00FDzkumu p\u0159\u00EDpravy pevn\u00FDch polymern\u00EDch nosi\u010D\u016F a jejich vyu\u017Eit\u00ED k imobilizaci biologicky aktivn\u00EDch l\u00E1tek. Nov\u011B budou vyv\u00EDjeny nosi\u010De ve form\u011B membr\u00E1n z p\u0159\u00EDrodn\u00EDch polymer\u016F a magnetick\u00E9 pevn\u00E9 nosi\u010De, kter\u00E9 usnadn\u00ED izolace produkt\u016F a odd\u011Blen\u00ED katalytick\u00E9ho syst\u00E9mu p\u0159i reakc\u00EDch v suspenzi. V\u00FDsledkem orientovan\u00E9 imobilizace enzym\u016F pomoc\u00ED protil\u00E1tek proti nim a imobilizace protil\u00E1tek prost\u0159ednictv\u00EDm jejich cukern\u00E9 slo\u017Eky je dobr\u00E1 sterick\u00E1 p\u0159\u00EDstupnost aktivn\u00EDho m\u00EDsta i zv\u00FD\u0161en\u00E1 stabilita takto imobilizovan\u00FDch enzym\u016F a protil\u00E1tek. Budou p\u0159ipraveny enzymov\u00E9 reaktory pro aktivaci cukern\u00E9 slo\u017Eky glykoprotein\u016F pro vazbu na hydrazidov\u00E9m nosi\u010Di. Proteolytick\u00E9 reaktory s enzymy v\u00E1zan\u00FDmi prost\u0159ednictv\u00EDm imunokomplex\u016F budou pou\u017Eity pro diagnostick\u00E9 \u00FA\u010Dely p\u0159i anal\u00FDze patologicky zm\u011Bn\u011Bn\u00FDch b\u00EDlkovin. P\u0159edpokl\u00E1d\u00E1 se praktick\u00E9 vyu\u017Eit\u00ED v\u00FDsledk\u016F a p\u0159eveden\u00ED do poloprovozn\u00EDch" . "0"^^ . . . . "The project is concentrated on application in bio-specific interactions for isolation and oriented immobilization of proteins. It is a continuation of a twenty five years Czech research on preparation of solid polymeric supports and their utilization forimmobilization of biologically active substances. Matrices in the form of membranes from natural polymers and magnetic beaded supports will be newly developed that will facilitate isolation of products and separation of catalytical systems from suspensioreaction systems. Oriented immobilizations of enzymes using antibodies against them and immobilization of antibodies through their carbohydrate moiety will be manifested in a good sterical accessibility of active site and enhanced stability of enzymes anantibodies immobilized in such a way. Enzyme reactors for activation of glycoprotein carbohydrate moiety for binding on hydrazide matrices will be prepared. Proteolytic reactors with enzymes bound through immunocomplex will be used for diagnostic purpose"@en . . "26"^^ . "26"^^ . "1"^^ . "Oriented immobilization of enzymes and antibodies using biospecific interactions"@en . . . . "0"^^ . "GA203/98/1231" . . . . . . "Orientovan\u00E1 imobilizace enzym\u016F a protil\u00E1tek s vyu\u017Eit\u00EDm biospecifick\u00FDch interakc\u00ED" . .