"3"^^ . . . "3"^^ . . "GA203/94/0933" . "Nov\u00E1 kancerostatika interkaluj\u00EDc\u00ED do nukleov\u00FDch kyselin." . "http://www.isvav.cz/projectDetail.do?rowId=GA203/94/0933"^^ . "0"^^ . . . . . . . . "Budou studov\u00E1ny nov\u00E9 interkaluj\u00EDc\u00ED struktury ve snaze nal\u00E9zt nov\u00E1 selektivn\u00ED kancerostatika.N\u00E1vrh nov\u00FDch struktur bude podlo\u017Een v\u00FDsledky molekul\u00E1rn\u00EDho modelov\u00E1n\u00ED struktur samotn\u00FDch i jejich komplex\u016F s DNK.V\u00FDb\u011Br struktur bude alespo\u0148 z po\u010D\u00E1tku vych\u00E1zet zezn\u00E1m\u00FDch interkaluj\u00EDc\u00EDch l\u00E1tek -mitoxantronu a echinomycinu.Tyto mono a bis-interkal\u00E1tory budou modifikov\u00E1ny jak v povaze plan\u00E1rn\u00EDho chromoforu, tak ve struktu\u0159e postrann\u00EDho \u0159et\u011Bzce, kter\u00FD bude nahrazen peptidick\u00FDm `rozpozn\u00E1vaj\u00EDc\u00EDm`elementem.Struktura i onformace (v roztoku) nov\u011B p\u0159ipraven\u00FDch l\u00E1tek bude studov\u00E1na spektroskopicky, povaha interakce s DNK nav\u00EDc elektromigra\u010Dn\u00EDmi technikami.Kancerostatick\u00E1 aktivita bude testov\u00E1na s pomoc\u00ED topoisomerasy II." . "Rational Design of New Anti-Cancer Drugs Acting as Intercalators of DNA."@en . . "1"^^ . . "1"^^ . .